LAVENDUSTIN A

• Catalog No.: 02158815
• CAS Number: 125697-92-9
• M. F.: C21H19NO6
• M. W.: 381.37866
• Storage: 0°C, Desiccate, Protect from light

SYNONYMS

• IUPAC name: 5-{[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino}-2-hydroxybenzoic acid
• IUPAC Traditional name: 5-{[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino}-2-hydroxybenzoic acid

DATABASE IDS

• CAS Number: 125697-92-9

PROPERTIES

• Storage Condition: 0°C, Desiccate, Protect from light

DETAILS

Description (English)

Lavendustin A is a potent and selective inhibitor of the EGF receptor tyrosine kinase (IC₅₀ =11 nM)^1 . It binds to a site on the kinase which is distinct from the ATP and peptide substrate binding sites^2 .

REFERENCES

• Onada, T., et al., J. Nat. Prod. , 52 : 1252, (1989).
• Hsu, C.-Y.J., et al., J. Biol. Chem. , 266 : 21105, (1991).