CALYCULIN A

• Catalog No.: 02158378
• CAS Number: 101932-71-2
• M. F.: C50H81N4O15P
• M. W.: 1009.169701
• Purity: ≥95%
• Storage: -20°C

SYNONYMS

• IUPAC name: {[2-(14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyltetradeca-7,9,11,13-tetraen-1-yl)-7-[3-(2-{4-[4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanamido]butan-2-yl}-1,3-oxazol-4-yl)prop-2-en-1-yl]-9-hydroxy-4,4,8-trimethyl-1,6-dioxaspiro[4.5]decan-3-yl]oxy}phosphonic acid
• IUPAC Traditional name: [2-(14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyltetradeca-7,9,11,13-tetraen-1-yl)-7-[3-(2-{4-[4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanamido]butan-2-yl}-1,3-oxazol-4-yl)prop-2-en-1-yl]-9-hydroxy-4,4,8-trimethyl-1,6-dioxaspiro[4.5]decan-3-yl]oxyphosphonic acid

DATABASE IDS

• CAS Number: 101932-71-2

PROPERTIES

• Purity: ≥95%
• Storage Condition: -20°C

DETAILS

Description (English)

Purity: >95%
Phosphatase inhibitor with very potent inhibitory activity against both PP1 and PP2A phosphatases.
IC₅₀ values of approximately 1 nm for both PP1 and PP2A.

REFERENCES

• Ishihara, H., et al., Biochem. Biophys. Res. Commun. , 159 : 871 (1989).
• Suganuma, M., et al., Cancer Res. , 50 : 3521 (1990).