DIACYLGLYCEROL KINASE INHIBITOR I

• Catalog No.: 02152409
• CAS Number: 93076-89-2
• M. F.: C27H26FN3OS
• M. W.: 459.5782432
• Storage: Room Temperature (15-30°C)

SYNONYMS

• IUPAC name: 6-(2-{4-[(4-fluorophenyl)(phenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
• IUPAC Traditional name: 6-(2-{4-[(4-fluorophenyl)(phenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
• Synonyms: R59022; 6-[2-[4-[(4-fluorophenyl)phenyl-methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidin-5-one; DKI

DATABASE IDS

• CAS Number: 93076-89-2

PROPERTIES

• Storage Condition: Room Temperature (15-30°C)

DETAILS

Description (English)

The elevation of diacylglycerol became of major importance when diacylglycerol was shown to stimulate protein kinase C, making this lipid candidate for a second messenger function in the signal transduction system. In intact cells, diacylglycerol is rapidly phosphorylated into phosphatidic acid by diacylglycerol kinase and reverses the protein kinase C activity.
DKI was found to inhibit diacylglycerol kinase. In human red blood cell membranes and in intact platelets, the concentrations needed for half maximal inhibition ranged from 2 to 4x10^-6M.