Aminophenazone

• Catalog No.: DB01424
• CAS Number: 58-15-1
• M. F.: C13H17N3O
• M. W.: 231.29358

SYNONYMS

• IUPAC name: 4-(dimethylamino)-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one
• IUPAC Traditional name: aminophenazone
• Synonyms: 4-Dimethylaminoantipyrine; Dipyrine; Aminopyrine

DATABASE IDS

• CAS Number: 58-15-1
• PubChem CID: 6009
• PubChem SID: 46504975

PROPERTIES

• Hydrophobicity(logP): 1.00 [HANSCH,C ET AL. (1995)]
• Solubility: 54.4 mg/mL at 30 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

DETAILS

Description (English)

• Drug Groups: approved; withdrawn
• Description: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests. [PubChem]
• Indication: Formerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds. Currently used to measure total body water.
• Pharmacology: Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests. [Wikipedia]
• Toxicity: Can cause life-threatening agranulocytosis.
• Affected Organisms: Humans and other mammals
• References: Rating D, Langhans CD: Breath tests: concepts, applications and limitations. Eur J Pediatr. 1997 Aug;156 Suppl 1:S18-23. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Rating D, Langhans CD: Breath tests: concepts, applications and limitations. Eur J Pediatr. 1997 Aug;156 Suppl 1:S18-23. Pubmed