Paromomycin

• Catalog No.: DB01421
• CAS Number: 1263-89-4
• M. F.: C23H45N5O14
• M. W.: 615.6285

SYNONYMS

• IUPAC name: (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}-2-(hydroxymethyl)oxane-3,4-diol
• IUPAC Traditional name: (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}-2-(hydroxymethyl)oxane-3,4-diol
• Brand Name: Humatin
• Synonyms: Paramomycin sulfate; Aminosidine; paromomycin; Aminosidin

DATABASE IDS

• PubChem CID: 165580
• CAS Number: 1263-89-4
• PubChem SID: 46505391

DETAILS

Description (English)

• Drug Groups: approved; investigational
• Description: An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
• Indication: For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
• Pharmacology: Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.
• Affected Organisms: Enteric bacteria and other eubacteria
• Absorption: Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.
• References: Vicens Q, Westhof E: Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site. Structure. 2001 Aug;9(8):647-58. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

REFERENCES

• Vicens Q, Westhof E: Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site. Structure. 2001 Aug;9(8):647-58. Pubmed