Pranlukast

• Catalog No.: DB01411
• CAS Number: 103177-37-3
• M. F.: C27H23N5O4
• M. W.: 481.50262

SYNONYMS

• IUPAC name: N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)-4H-chromen-7-yl]-4-(4-phenylbutoxy)benzamide
• IUPAC Traditional name: @pranlukast
• Synonyms: ONO-RS 411

DATABASE IDS

• PubChem CID: 115100
• PubChem SID: 46508129
• CAS Number: 103177-37-3

DETAILS

Description (English)

• Drug Groups: approved
• Description: Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
• Indication: Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists.
• Pharmacology: Pranlukast is a cysteinyl leukotriene receptor-1 antagonist.
• Toxicity: Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic
• References: Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S: Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. Drug Metab Pharmacokinet. 2006 Apr;21(2):133-9. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S: Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. Drug Metab Pharmacokinet. 2006 Apr;21(2):133-9. Pubmed