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Pranlukast

Catalog No. DB01411 Name DrugBank
CAS Number 103177-37-3 Website http://www.ualberta.ca/
M. F. C27H23N5O4 Telephone (780) 492-3111
M. W. 481.50262 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 1220

SYNONYMS

IUPAC name
N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)-4H-chromen-7-yl]-4-(4-phenylbutoxy)benzamide
IUPAC Traditional name
@pranlukast
Synonyms
ONO-RS 411

DATABASE IDS

PubChem CID 115100
PubChem SID 46508129
CAS Number 103177-37-3

PROPERTIES

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
Indication Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists.
Pharmacology Pranlukast is a cysteinyl leukotriene receptor-1 antagonist.
Toxicity Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
References
Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S: Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. Drug Metab Pharmacokinet. 2006 Apr;21(2):133-9. [Pubmed]
External Links
Wikipedia

REFERENCES

  • Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S: Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. Drug Metab Pharmacokinet. 2006 Apr;21(2):133-9. Pubmed