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Cortisone acetate_Molecular_structure_CAS_50-04-4)
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Cortisone acetate

Catalog No. DB01380 Name DrugBank
CAS Number 50-04-4 Website http://www.ualberta.ca/
M. F. C23H30O6 Telephone (780) 492-3111
M. W. 402.4807 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 1198

SYNONYMS

IUPAC name
2-[(1S,2R,10S,11S,14R,15S)-14-hydroxy-2,15-dimethyl-5,17-dioxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl]-2-oxoethyl acetate
IUPAC Traditional name
cortisone acetate

DATABASE IDS

PubChem CID 5745
CAS Number 50-04-4
PubChem SID 46508852

PROPERTIES

Hydrophobicity(logP) 2.10 [HANSCH,C ET AL. (1995)]
Solubility 0.02 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Cortisone acetate is a steroid hormone that has both glucocoriticoid and mineral corticoid activities. Corticosteroids are used to provide relief for inflamed areas of the body. They lessen swelling, redness, itching, and allergic reactions. They are often used as part of the treatment for a number of different diseases, such as severe allergies or skin problems, asthma, or arthritis. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, corticosteroid-binding protein), whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor.
Indication For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders.
Pharmacology As a glucocorticoid agent, cortisone acetate changes genetic transcription levels causing varied metabolic effects and a modified immune response to varied stimuli. lucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.
Toxicity Side effects include inhibition of bone formation, suppression of calcium absorption, delayed wound healing and hyperglycemia.
Affected Organisms
Humans and other mammals
Elimination Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
External Links
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REFERENCES