| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248) |
| Indication |
Used to maintain blood pressure in hypotensive states. |
| Pharmacology |
Mephentermine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248) |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Hepatic, by N-demethylation and then p-hydroxylation. |
| Half Life |
17 to 18 hours. |
|