| Item |
Information |
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Drug Groups
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approved |
|
Description
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Penbutolol is a medication in the class of beta blockers, used in the treatment of high blood pressure. [Wikipedia] |
| Indication |
Used in the treatment of high blood pressure. |
| Pharmacology |
Penbutolol is a non-selective beta blocker. Beta-blockers work by affecting the response to some nerve impulses in certain parts of the body. As a result, they decrease the heart's need for blood and oxygen by reducing its workload. They also help the heart to beat more regularly. |
| Toxicity |
Symptoms of overdose include drowsiness, vertigo, headache, and atriventricular block. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Metabolized in the liver by hydroxylation and glucuroconjugation forming a glucuronide metabolite and a semi-active 4-hydroxy metabolite. |
| Absorption |
Oral bioavailability is 90%. |
| Half Life |
Phase 1: 2.5 hours; phase 2: 24 hours |
| Protein Binding |
80-98% bound to plasma proteins. |
| Elimination |
The metabolites are excreted principally in the urine. |
| External Links |
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