Aminosalicylic Acid

• Catalog No.: DB00233
• CAS Number: 65-49-6
• M. F.: C7H7NO3
• M. W.: 153.13538

SYNONYMS

• IUPAC name: 4-amino-2-hydroxybenzoic acid
• IUPAC Traditional name: aminosalicylic acid
• Brand Name: Propasa; Pamisyl; Pasara; Sanipriol-4; Apacil; Kyselina P-Aminosalicylova; Para-Pas; Parasal; Parasalindon; Pasa; Pascorbic; Pasem; Paser; Pasolac; Aminopar; Aminox; Deapasil; Entepas; Gabbropas; Hellipidyl; Neopasalate; Osacyl; PAS-C; Pamacyl; Paramycin; Parasalicil; Pasalon; Pasnodia; Rezipas; Sanipirol-4; Ferrosan; Pasdium; Pasmed
• Synonyms: Para-aminosalicylic acid; APAS; PAS; Aminosalicylate Sodium; P-Aminosalicylic Acid; Para-Amino Salicylic Acid; 4-aminosalicylic acid; 4-ASA; PASK; Amino-PAS

DATABASE IDS

• CAS Number: 65-49-6
• PubChem SID: 46505572
• PubChem CID: 4649

PROPERTIES

• Hydrophobicity(logP): 1.6
• Solubility: 1690 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: An antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid. [PubChem]
• Indication: For the treatment of tuberculosis
• Pharmacology: Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.
• Toxicity: LD₅₀=4 gm/kg (orally in mice); LD₅₀=3650 mg/kg (orally in rabbits)
• Affected Organisms: Mycobacteria
• Biotransformation: Hepatic.
• Protein Binding: 50-60%
• External Links: Wikipedia; RxList; Drugs.com