Pancuronium

• Catalog No.: DB01337
• CAS Number: 15500-66-0
• M. F.: C35H60N2O4++
• M. W.: 572.8619

SYNONYMS

• IUPAC name: 1-[(1S,2S,4S,5S,7S,10R,11S,13S,14R,15S)-5,14-bis(acetyloxy)-2,15-dimethyl-4-(1-methylpiperidin-1-ium-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1-methylpiperidin-1-ium
• IUPAC Traditional name: 1-[(1S,2S,4S,5S,7S,10R,11S,13S,14R,15S)-5,14-bis(acetyloxy)-2,15-dimethyl-4-(1-methylpiperidin-1-ium-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1-methylpiperidin-1-ium
• Brand Name: Pavulon; Mioblock
• Synonyms: Pancuronium bromide; Bromure de pancuronium [inn-french]; Bromuro de pancuronio [inn-spanish]; Pancuronium dibromide

DATABASE IDS

• CAS Number: 15500-66-0
• PubChem SID: 46506118
• PubChem CID: 441289

PROPERTIES

• Solubility: 500 mg/mL [MERCK INDEX (1996)]

DETAILS

Description (English)

• Drug Groups: approved
• Description: A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.
• Indication: Used as a muscle relaxant during anesthesia and surgical procedures.
• Pharmacology: Pancuronium is a typical non-depolarising curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is, unlike suxamethonium, a non-depolarising agent, which means, that it causes no spontaneous depolarisations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration. Pancuronium has no hormonal activity. It exerts slight vagolytic activity (i.e. diminishing activity of the vagus nerve) and no ganglioplegic (i.e., blocking ganglions) activity.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Half Life: 1.5 to 2.7 hours.
• Protein Binding: 77 to 91%
• Distribution: * 241 to 280 mL/kg
• Clearance: * Plasma cl=1.1–1.9 mL/minute/kg
• External Links: Wikipedia