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Ergonovine

Catalog No. DB01253 Name DrugBank
CAS Number 60-79-7 Website http://www.ualberta.ca/
M. F. C19H23N3O2 Telephone (780) 492-3111
M. W. 325.40482 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 1122

SYNONYMS

IUPAC name
(4R,7R)-N-[(2S)-1-hydroxypropan-2-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide
IUPAC Traditional name
ergonovine
Brand Name
Ergotrate
Synonyms
Ergotrate maleate
Ergobasine
Ergometrine

DATABASE IDS

PubChem SID 46506922
PubChem CID 443884
CAS Number 60-79-7

PROPERTIES

Hydrophobicity(logP) 0.9
Solubility 2.68 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]

DETAILS

Description (English)
Item Information
Drug Groups approved
Description An ergot alkaloid with uterine and vascular smooth muscle contractile properties. [PubChem]
Indication Used to treat postpartum haemorrhage and postabortion haemorrhage in patients with uterine atony.
Pharmacology Ergonovine belongs to the group of medicines known as ergot alkaloids. These medicines are usually given to stop excessive bleeding that sometimes occurs after abortion or a baby is delivered. They work by causing the muscle of the uterus to contract.
Toxicity The principal symptoms of overdose are convulsions and gangrene. Other symptoms include bradycardia, confusion, diarrhoea, dizziness, dyspnoea, drowsiness, fast and/or weak pulse, miosis, hypercoagulability, loss of consciousness, nausea and vomiting, numbness and coldness of the extremities, pain in the chest, peripheral vasoconstriction, respiratory depression, rise or fall in blood pressure, severe cramping of the uterus, tachycardia, tingling, and unusual thirst.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Absorption Absorption is rapid and complete after oral or intramuscular administration.
Half Life t1/2 α=10 minutes; t1/2 β=2 hours
Elimination Thought to be eliminated by non-renal mechanisms (i.e. hepatic metabolism, excretion in feces)
External Links
Wikipedia
Drugs.com

REFERENCES