| Item |
Information |
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Drug Groups
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approved |
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Description
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Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. [Wikipedia] |
| Indication |
Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery. |
| Pharmacology |
Sevoflurane (also called fluoromethyl) is a halogenated ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. It is often administered in nitrous oxide and pure oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offset. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential. |
| Toxicity |
LC50=49881 ppm/hr (rat), LD50=10.8 g/kg (rat) |
| Affected Organisms |
| • |
Humans and other mammals |
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| Biotransformation |
Relatively little biotransformation, only 5% is metabolized by cytochrome P450 CYP2E1 to hexafluoroisopropanol (HFIP) with release of inorganic fluoride and CO2. No other metabolic pathways have been identified for sevoflurane. |
| Absorption |
Rapidly absorbed into circulation via the lungs, however solubility in the blood is low. |
| Half Life |
15-23 hours |
| Elimination |
The low solubility of sevoflurane facilitates rapid elimination via the lungs. In vivo metabolism studies suggest that approximately 5% of the sevoflurane dose may be metabolized. Up to 3.5% of the sevoflurane dose appears in the urine as inorganic fluoride. |
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