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Guanadrel Sulfate

Catalog No. DB00226 Name DrugBank
CAS Number 22195-34-2 Website http://www.ualberta.ca/
M. F. C10H19N3O2 Telephone (780) 492-3111
M. W. 213.27676 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 111


IUPAC name
IUPAC Traditional name
guanadrel sulfate
Brand Name
Guanadrelum [INN-Latin]


PubChem SID 46506457
PubChem CID 38521
CAS Number 22195-34-2


Hydrophobicity(logP) 0.6


Description (English)
Item Information
Drug Groups approved
Description Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter.
Indication Used to treat and control hypertension.
Pharmacology High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guanadrel works by controlling nerve impulses along certain nerve pathways. As a result, it relaxes the blood vessels so that blood passes through them more easily. This helps to lower blood pressure.
Toxicity Side effects include dizziness, drowsiness, headache, constipation, diarrhea, gas pains, loss of appetite, fatigue, and nasal congestion.
Affected Organisms
Humans and other mammals
Biotransformation Primarily hepatic
Absorption Rapidly and readily absorbed from the gastrointestinal tract.
Half Life 10 hours
Protein Binding Low, approximately 20%
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