Dexamethasone

• Catalog No.: DB01234
• CAS Number: 50-02-2
• M. F.: C22H29FO5
• M. W.: 392.4610632

SYNONYMS

• IUPAC name: (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
• IUPAC Traditional name: dexamethasone
• Brand Name: Dinormon; Visumetazone; Hexadrol Tablets; Dexamethasone Intensol; Dexinolon; Dezone; Decasone; Dexa-Cortisyl; Dexasone; Dexone 4; Dexonium; Loverine; Maxitrol; Millicorten; Pet Derm Iii; Spoloven; Turbinaire; Corson; Decacort; Decagel; Dectancyl; Deltafluorene; Deronil; Desadrene; Dexa-Scheroson; Dexa-Sine; Dexacortin; Dexalona; Dexapolcort; Dexapos; Dexone 0.5; Dexone 1.5; Fluormone; Gammacorten; Hexadrol Elixir; Luxazone; Prednisolone F; Adexone; Aeroseb-Dex; Anaflogistico; Aphtasolon; Aphthasolone; Auxiron; Azium; Bisu Ds; Corsone; Decaderm; Decadron; Decadron Tablets, Elixir; Dekacort; Dergramin; Desameton; Dex-Ide; Dexa; Dexa-Cortidelt; Dexacort; Dexacortal; Dexadeltone; Dexafarma; Dexair; Dexamonozon; Dexaprol; Dexason; Dexinoral; Dexone 0.75; Dextelan; Fluorocort; Fortecortin; Hexadecadrol; Hexadrol; Isopto-Dex; Lokalison F; Maxidex; Mediamethasone; Mexidex; Ocu-Trol; Pet-Derm Iii; Sk-Dexamethasone; Superprednol; Posurdex; IontoDex; Aeroseb-D; Calonat; Cortisumman; Decacortin; Decadron-La; Decalix; Decaspray; Deseronil; Dexa Mamallet; Dexa-Mamallet; Dexacen-4; Dexacidin; Dexaltin; Dexameth; Dexone; Hl-Dex; Mymethasone; Oradexon; Policort; Prednisolon F; Sunia Sol D
• Synonyms: Desamethasone; Desametasone; Dexametasona [INN-Spanish]; Desametasone [DCIT]; Dexamethasonum [INN-Latin]; Dexamethazone; Fluormethylprednisolone; Dexamethasone Acetate; Dexamethasone Sodium Phosphate

DATABASE IDS

• CAS Number: 50-02-2
• PubChem CID: 5743
• PubChem SID: 46508930

PROPERTIES

• Hydrophobicity(logP): 1.1
• Solubility: 89 mg/L

DETAILS

Description (English)

• Drug Groups: approved; investigational
• Description: An anti-inflammatory 9-fluoro-glucocorticoid. [PubChem]
• Indication: Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.; ; Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.; ; Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus; ; Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses; ; Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy; ; Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
• Pharmacology: Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.
• Toxicity: Oral, rat LD₅₀: >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Absorption: 80-90%
• Half Life: 36-54 hours
• Protein Binding: 70%
• External Links: Wikipedia; RxList; PDRhealth; Drugs.com