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Dexamethasone

Catalog No. DB01234 Name DrugBank
CAS Number 50-02-2 Website http://www.ualberta.ca/
M. F. C22H29FO5 Telephone (780) 492-3111
M. W. 392.4610632 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 1103

SYNONYMS

IUPAC name
(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
IUPAC Traditional name
dexamethasone
Brand Name
Dinormon
Visumetazone
Hexadrol Tablets
Dexamethasone Intensol
Dexinolon
Dezone
Decasone
Dexa-Cortisyl
Dexasone
Dexone 4
Dexonium
Loverine
Maxitrol
Millicorten
Pet Derm Iii
Spoloven
Turbinaire
Corson
Decacort
Decagel
Dectancyl
Deltafluorene
Deronil
Desadrene
Dexa-Scheroson
Dexa-Sine
Dexacortin
Dexalona
Dexapolcort
Dexapos
Dexone 0.5
Dexone 1.5
Fluormone
Gammacorten
Hexadrol Elixir
Luxazone
Prednisolone F
Adexone
Aeroseb-Dex
Anaflogistico
Aphtasolon
Aphthasolone
Auxiron
Azium
Bisu Ds
Corsone
Decaderm
Decadron
Decadron Tablets, Elixir
Dekacort
Dergramin
Desameton
Dex-Ide
Dexa
Dexa-Cortidelt
Dexacort
Dexacortal
Dexadeltone
Dexafarma
Dexair
Dexamonozon
Dexaprol
Dexason
Dexinoral
Dexone 0.75
Dextelan
Fluorocort
Fortecortin
Hexadecadrol
Hexadrol
Isopto-Dex
Lokalison F
Maxidex
Mediamethasone
Mexidex
Ocu-Trol
Pet-Derm Iii
Sk-Dexamethasone
Superprednol
Posurdex
IontoDex
Aeroseb-D
Calonat
Cortisumman
Decacortin
Decadron-La
Decalix
Decaspray
Deseronil
Dexa Mamallet
Dexa-Mamallet
Dexacen-4
Dexacidin
Dexaltin
Dexameth
Dexone
Hl-Dex
Mymethasone
Oradexon
Policort
Prednisolon F
Sunia Sol D
Synonyms
Desamethasone
Desametasone
Dexametasona [INN-Spanish]
Desametasone [DCIT]
Dexamethasonum [INN-Latin]
Dexamethazone
Fluormethylprednisolone
Dexamethasone Acetate
Dexamethasone Sodium Phosphate

DATABASE IDS

CAS Number 50-02-2
PubChem CID 5743
PubChem SID 46508930

PROPERTIES

Hydrophobicity(logP) 1.1
Solubility 89 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved; investigational
Description An anti-inflammatory 9-fluoro-glucocorticoid. [PubChem]
Indication Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.

Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.

Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus

Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses

Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy

Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
Pharmacology Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.
Toxicity Oral, rat LD50: >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Absorption 80-90%
Half Life 36-54 hours
Protein Binding 70%
External Links
Wikipedia
RxList
PDRhealth
Drugs.com

REFERENCES