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Diflorasone

Catalog No. DB00223 Name DrugBank
CAS Number 2557-49-5 Website http://www.ualberta.ca/
M. F. C26H32F2O7 Telephone (780) 492-3111
M. W. 494.5248864 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 108

SYNONYMS

IUPAC name
2-[(1R,2S,8S,10S,11S,13S,14R,15S,17S)-14-(acetyloxy)-1,8-difluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl acetate
IUPAC Traditional name
diflorasone
Brand Name
Psorcon
Florone
Florone E
Maxiflor
Synonyms
Diflorasone Diacetate

DATABASE IDS

CAS Number 2557-49-5

PROPERTIES

Hydrophobicity(logP) 2.1

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin.
Indication For relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
Pharmacology Like other topical corticosteroids, diflorasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Diflorasone is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
Toxicity Topically applied diflorasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Affected Organisms
Humans and other mammals
Biotransformation Metabolized, primarily in the liver, and then excreted by the kidneys.
Absorption Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
Protein Binding Bound to plasma proteins in varying degrees.
External Links
Wikipedia
RxList
Drugs.com

REFERENCES