Domperidone

• Catalog No.: DB01184
• CAS Number: 57808-66-9
• M. F.: C22H24ClN5O2
• M. W.: 425.91126

SYNONYMS

• IUPAC name: 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
• IUPAC Traditional name: motilium
• Brand Name: Lopac-D-122; Motilium; Nauzelin

DATABASE IDS

• CAS Number: 57808-66-9
• PubChem CID: 3151
• PubChem SID: 46508314

PROPERTIES

• Hydrophobicity(logP): 2.4
• Solubility: 0.986 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. [PubChem]
• Indication: For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
• Pharmacology: Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
• Toxicity: Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
• Affected Organisms: Humans and other mammals
• Absorption: Fast
• Half Life: 7 hours
• Protein Binding: 91%-93%
• References: Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EM, McCallum R, Leidy NK, Farup C, Liu Y, Joslyn A: Domperidone in the management of symptoms of diabetic gastroparesis: efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. DOM-USA-5 Study Group. Clin Ther. 1998 May-Jun;20(3):438-53. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EM, McCallum R, Leidy NK, Farup C, Liu Y, Joslyn A: Domperidone in the management of symptoms of diabetic gastroparesis: efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. DOM-USA-5 Study Group. Clin Ther. 1998 May-Jun;20(3):438-53. Pubmed