Rescinnamine

• Catalog No.: DB01180
• CAS Number: 24815-24-5
• M. F.: C35H42N2O9
• M. W.: 634.71598

SYNONYMS

• IUPAC name: methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-{[3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylate
• IUPAC Traditional name: rescinnamine
• Brand Name: Paresinan; Rescisan; Apolon; Rescidan; Anapral; Anaprel; Apoterin S; Cinamine; Cinnasil; Raurescin; Rescinpal; Tuareg; Apoterin; Cartric; Cinatabs; Cinnaloid; Moderil; Normorescina; Raupyrol; Raurescine; Recitensina; Rescaloid; Rescamin; Rescin; Rescitens; Resealoid; Resipal; Reskinnamin; Rozex; Scinnamina; Tenamine; Tsuruselpi S
• Synonyms: Recinnamine; Reserpinine; Methyl Trimethoxycinnamoylreserpate; Trimethoxycinnamoyl Methyl Reserpate; Rescinnamin; Reserpinene; Reserpinin

DATABASE IDS

• CAS Number: 24815-24-5
• PubChem CID: 5280954
• PubChem SID: 46507786

PROPERTIES

• Hydrophobicity(logP): 3.5

DETAILS

Description (English)

• Drug Groups: approved
• Description: Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug. It is an alkaloid obtained from Rauwolfia serpentina and other species of Rauwolfia. [Wikipedia]
• Indication: For the treatment of hypertension.
• Pharmacology: Used to treat hypertension. Rescinnamine inhibits angiotensin-converting enzyme. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex and general vasoconstriction, both of which lead to increases vascular resistance. By inhibiting angiotensin II, aldosterone reabsorption is decreased as well as vasoconstriction. This combined effect serves to decrease blood pressure.
• Affected Organisms: Humans and other mammals
• External Links: Wikipedia