Podofilox

• Catalog No.: DB01179
• CAS Number: 477-47-4
• M. F.: C22H22O8
• M. W.: 414.40528

SYNONYMS

• IUPAC name: (10R,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one
• IUPAC Traditional name: podofilox
• Brand Name: Podophyllotoxin; Podophyllotoxin 7
• Synonyms: Podophyllinic acid lactone

DATABASE IDS

• PubChem CID: 10607
• CAS Number: 477-47-4
• PubChem SID: 46505716

PROPERTIES

• Hydrophobicity(logP): 1.5
• Solubility: 100 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: A lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. [PubChem]
• Indication: For treatment of external genital warts (Condyloma acuminatum).
• Pharmacology: Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas.
• Affected Organisms: Condyloma acuminatum
• Absorption: Topical application of 0.05 mL of 0.5% podofilox solution to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5 mL resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application.
• Half Life: 1.0 to 4.5 hours.
• External Links: Wikipedia; RxList; Drugs.com