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Oxyphenonium

Catalog No. DB00219 Name DrugBank
CAS Number 50-10-2 Website http://www.ualberta.ca/
M. F. C21H34NO3+ Telephone (780) 492-3111
M. W. 348.49956 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 104

SYNONYMS

IUPAC name
{2-[(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]ethyl}diethylmethylazanium
IUPAC Traditional name
spasmophen
Brand Name
Methacin
Methocidin
Antrenyl
Argicillin
Synonyms
Methocidin [Dcf:Inn]
Oxiphenonum
Hydroxymethylgramicidin
Methocidinum [INN-Latin]
Methocidine [INN-French]
Metocidina [INN-Spanish]
Oxyphenonium Bromide
DCF

DATABASE IDS

PubChem SID 46508840
PubChem CID 5749
CAS Number 50-10-2

PROPERTIES

Hydrophobicity(logP) 0.17

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect. [PubChem]
Indication For the treatment of visceral spasms
Pharmacology Oxyphenonium is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Oxyphenonium is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Oxyphenonium inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Affected Organisms
Humans and other mammals
Protein Binding 93% bound to albumin

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