Cloxacillin

• Catalog No.: DB01147
• CAS Number: 61-72-3
• M. F.: C19H18ClN3O5S
• M. W.: 435.88132

SYNONYMS

• IUPAC name: (2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• IUPAC Traditional name: (2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• Brand Name: Novo-Cloxin; Nu-Cloxi
• Synonyms: Cloxacillin Sodium

DATABASE IDS

• PubChem CID: 6098
• CAS Number: 61-72-3
• PubChem SID: 46507109

PROPERTIES

• Hydrophobicity(logP): 3
• Solubility: 13.9 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem]
• Indication: Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
• Pharmacology: Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase.
• Toxicity: Oral LD₅₀ in rat and mouse is 5000 mg/kg. Intravenous LD₅₀ in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
• Affected Organisms: Enteric bacteria and other eubacteria
• Absorption: Well absorbed from the gastrointestinal tract.
• Protein Binding: 95%
• External Links: Wikipedia; Drugs.com