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Cloxacillin

Catalog No. DB01147 Name DrugBank
CAS Number 61-72-3 Website http://www.ualberta.ca/
M. F. C19H18ClN3O5S Telephone (780) 492-3111
M. W. 435.88132 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 1018

SYNONYMS

IUPAC name
(2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
IUPAC Traditional name
(2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Brand Name
Novo-Cloxin
Nu-Cloxi
Synonyms
Cloxacillin Sodium

DATABASE IDS

PubChem CID 6098
CAS Number 61-72-3
PubChem SID 46507109

PROPERTIES

Hydrophobicity(logP) 3
Solubility 13.9 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem]
Indication Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
Pharmacology Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase.
Toxicity Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption Well absorbed from the gastrointestinal tract.
Protein Binding 95%
External Links
Wikipedia
Drugs.com

REFERENCES