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Econazole

Catalog No. DB01127 Name DrugBank
CAS Number 27220-47-9 Website http://www.ualberta.ca/
M. F. C18H15Cl3N2O Telephone (780) 492-3111
M. W. 381.6835 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 998

SYNONYMS

IUPAC name
1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
IUPAC Traditional name
econazole
Brand Name
Gyno-Pevaryl
Ifenec
Palavale
Spectazole
Spectazole cream
Ecostatin
Econazole Nitrate
Ecostatin Vaginal Ovules
Ecostatin cream
Gyno-Pevaryl 150
Pevaryl

DATABASE IDS

PubChem SID 46508881
PubChem CID 3198
CAS Number 27220-47-9

PROPERTIES

Hydrophobicity(logP) 5.5

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. [PubChem]
Indication For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
Pharmacology Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
Toxicity Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.
Affected Organisms
Yeast and other fungi
Biotransformation Hepatic.
Absorption After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
External Links
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REFERENCES