2,2,6,6-tetramethylpiperidin-4-ol

• ChemBase ID: 91301
• Molecular Formular: C9H19NO
• Molecular Mass: 157.25326
• Monoisotopic Mass: 157.14666423
• SMILES: N1C(C)(CC(CC1(C)C)O)C
• Canonical SMILES: OC1CC(C)(C)NC(C1)(C)C
• InChI: InChI=1S/C9H19NO/c1-8(2)5-7(11)6-9(3,4)10-8/h7,10-11H,5-6H2,1-4H3
• InChIKey: VDVUCLWJZJHFAV-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 2,2,6,6-tetramethylpiperidin-4-ol
• IUPAC Traditional name: 2,2,6,6-tetramethylpiperidin-4-ol
• Synonyms: 2,2,6,6-Tetramethylpiperidin-4-ol; 4-Hydroxy-2,2,6,6-tetramethylpiperidine 98%; 4-Hydroxy-2,2,6,6-tetramethylpiperidine; 2,2,6,6-Tetramethyl-4-piperidinol; 2,2,6,6-Tetramethyl-4-piperidinol; 4-Hydroxy-2,2,6,6-tetramethylpiperidine; 2,2,6,6-Tetramethyl-4-hydroxypiperidine; Lastar A; NSC 16575; 2,2,6,6-Tetramethyl-4-piperidinol; 4-羟基-2,2,6,6-四甲基哌啶; 2,2,6,6-四甲基-4-哌啶醇; 4-羟基-2, 2, 6, 6-四甲氧基哌啶

Database IDs

• CAS Number: 2403-88-5
• EC Number: 219-291-2
• MDL Number: MFCD00005983
• Beilstein Number: 105039
• PubChem SID: 162078005; 24847236
• PubChem CID: 75471

CALCULATED PROPERTIES

• Acid pKa: 15.144971
• H Acceptors: 2
• H Donor: 2
• LogD (pH = 5.5): -2.7033675
• LogD (pH = 7.4): -2.0619173
• Log P: 0.5194845
• Molar Refractivity: 46.5317 cm^3
• Polarizability: 18.725828 Å^3
• Polar Surface Area: 32.26 Å^2
• Rotatable Bonds: 0
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: methanol: soluble0.1 g/mL, clear
• Melting Point: 129-131 °C(lit.); 129-133°C; 129-133°C; 130-132 °C
• Boiling Point: 212-215 °C(lit.); 212-215°C; 212-215°C
• Flash Point: 124°C(255°F)
• Density: 1.085

Safety Information

• Storage Warning: Corrosive
• European Hazard Symbols: Corrosive (C)
• UN Number: UN3259
• German water hazard class: 1
• Hazard Class: 8
• Packing Group: III
• Risk Statements: 34; 34-43
• Safety Statements: 26-36/37/39-45
• TSCA Listed: 是
• GHS Pictograms: GHS05; GHS07
• GHS Signal Word: Danger
• GHS Hazard statements: H314-H317; H314-H318; H315-H317-H318-H413
• GHS Precautionary statements: P280-P305 + P351 + P338; P280-P305 + P351 + P338-P310; P280-P305+P351+P338-P309-P310
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Product Information

• Purity: ≥99.0% (NT); 98%
• Grade: purum
• Empirical Formula (Hill Notation): C9H19NO

DETAILS

Sigma Aldrich - 115746

Packaging
10, 25 g in glass bottle
Application
Used as:
• An additive for polymer modified hindered amine light stabilizers1,2
• A light stabilizer for polyamide 66 fibers containing acid blue dyes3

Sigma Aldrich - 56515

Application
Used as:
• An additive for polymer modified hindered amine light stabilizers1,2
• A light stabilizer for polyamide 66 fibers containing acid blue dyes3

Toronto Research Chemicals - T304625

An intermediate in the preparation of Piperidinyloxy free radical derivatives.

REFERENCES

• Irie, O., et al.: Bioorg. Med. Chem. Lett., 18, 5280 (2008)