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306-40-1 molecular structure
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trimethyl[2-({4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl}oxy)ethyl]azanium

ChemBase ID: 87
Molecular Formular: C14H30N2O4++
Molecular Mass: 290.399
Monoisotopic Mass: 290.22055745
SMILES and InChIs

SMILES:
O(CC[N+](C)(C)C)C(=O)CCC(=O)OCC[N+](C)(C)C
Canonical SMILES:
O=C(OCC[N+](C)(C)C)CCC(=O)OCC[N+](C)(C)C
InChI:
InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2
InChIKey:
AXOIZCJOOAYSMI-UHFFFAOYSA-N

Cite this record

CBID:87 http://www.chembase.cn/molecule-87.html

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NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
trimethyl[2-({4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl}oxy)ethyl]azanium
IUPAC Traditional name
succinylcholine
Brand Name
Anectine
Quelicin
Quelicin Preservative Free
Sucostrin
Synonyms
Succinylcholine Chloride
Suxamethonium chloride
Scoline
Succinylcholine
CAS Number
306-40-1
PubChem SID
46506023
160963550
PubChem CID
5314

DATA SOURCES

DATA SOURCES

All Sources Commercial Sources Non-commercial Sources
Data Source Data ID
PubChem 5314 external link
DrugBank DB00202 external link
Data Source Data ID Price

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem ALOGPS 2.1
H Acceptors H Donor
LogD (pH = 5.5) -8.394079  LogD (pH = 7.4) -8.394079 
Log P -8.394079  Molar Refractivity 100.9406 cm3
Polarizability 31.004166 Å3 Polar Surface Area 52.6 Å2
Rotatable Bonds 11  Lipinski's Rule of Five true 
Log P -2.49  LOG S -5.68 
Solubility (Water) 7.57e-04 g/l 

PROPERTIES

PROPERTIES

Bioassay(PubChem)

DETAILS

DETAILS

DrugBank DrugBank
DrugBank - DB00202 external link
Item Information
Drug Groups approved
Description A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. [PubChem]
Indication Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT)
Pharmacology Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Succinylcholine has no direct action on the uterus or other smooth muscle structures.
Affected Organisms
Humans and other mammals
Biotransformation By pseudocholinesterase, to succinylmonocholine and choline.
Elimination About 10% of the drug is excreted unchanged in the urine.
References
Jonsson M, Dabrowski M, Gurley DA, Larsson O, Johnson EC, Fredholm BB, Eriksson LI: Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology. 2006 Apr;104(4):724-33. [Pubmed]
External Links
Wikipedia
RxList
Drugs.com

REFERENCES

REFERENCES

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  • • Jonsson M, Dabrowski M, Gurley DA, Larsson O, Johnson EC, Fredholm BB, Eriksson LI: Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology. 2006 Apr;104(4):724-33. Pubmed
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PATENTS

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