NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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2-chloro-5-nitro-N-(pyridin-4-yl)benzamide
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IUPAC Traditional name
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2-chloro-5-nitro-N-(pyridin-4-yl)benzamide
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Synonyms
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T0070907
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2-Chloro-5-nitro-N-4-pyridinylbenzamide
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N1-(4-pyridyl)-2-chloro-5-nitrobenzamide
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2-Chloro-5-nitro-N-4-pyridinyl-benzamide
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Benzamide, 2-chloro-5-nitro-N-4-pyridinyl-
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T0070907
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T0070907
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CAS Number
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MDL Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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10.365898
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H Acceptors
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4
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H Donor
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1
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LogD (pH = 5.5)
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2.084955
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LogD (pH = 7.4)
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2.384497
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Log P
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2.3914871
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Molar Refractivity
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70.5599 cm3
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Polarizability
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25.885471 Å3
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Polar Surface Area
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85.13 Å2
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Rotatable Bonds
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3
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Lipinski's Rule of Five
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true
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DETAILS
DETAILS
Sigma Aldrich
TRC
Sigma Aldrich -
T8703
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Biochem/physiol Actions T0070907 is very similar in structure and activity to the PPAR-γ antagonist GW9662. T0070907 is more potent and has higher selectivity for PPAR-γ over all other subtypes (about 800-fold) whereas GW9662 has been reported to have some PPAR-α agonist activity. |
Toronto Research Chemicals -
C374760
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A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 μM and 1.8 μM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain. |
REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • Lee, G., et al: J. Biol. Chem., 277, 19649 (2003)
- • Schaefer, K.L., et al: Cancer Res., 65, 2251 (2003)
- • Masuda, T., et al.: Clin. Cancer Res., 11, 4012 (2003)
- • Raikwar, H.P., et al.: J. Neuroimmunol., 167, 99 (2005)
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PATENTS
PATENTS
PubChem Patent
Google Patent