6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine

• ChemBase ID: 77481
• Molecular Formular: C14H19N5O2
• Molecular Mass: 289.33296
• Monoisotopic Mass: 289.15387487
• SMILES: O(c1cc2c(cc1OC)nc(nc2N)N1CCNCC1)C
• Canonical SMILES: COc1cc2nc(nc(c2cc1OC)N)N1CCNCC1
• InChI: InChI=1S/C14H19N5O2/c1-20-11-7-9-10(8-12(11)21-2)17-14(18-13(9)15)19-5-3-16-4-6-19/h7-8,16H,3-6H2,1-2H3,(H2,15,17,18)
• InChIKey: APKHJGDGWQDBGM-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine
• IUPAC Traditional name: 6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine
• Synonyms: 4-Amino-6,7-dimethoxy-2-piperazin-1-ylquinazoline; 6,7-Dimethoxy-2-(1-piperazinyl)-4-quinazolinamine; 2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline; 4-Amino-2-(1-piperazinyl)-6,7-dimethoxyquinazoline; 4-Amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline; 2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline

Database IDs

• CAS Number: 60547-97-9
• MDL Number: MFCD00563872
• PubChem SID: 162042353
• PubChem CID: 616267

CALCULATED PROPERTIES

• H Acceptors: 7
• H Donor: 2
• LogD (pH = 5.5): -2.090294
• LogD (pH = 7.4): -0.21103351
• Log P: 1.1261531
• Molar Refractivity: 81.8708 cm^3
• Polarizability: 31.512623 Å^3
• Polar Surface Area: 85.53 Å^2
• Rotatable Bonds: 3
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: DMSO; Methanol
• Apperance: White Solid
• Melting Point: 219-221°C (dec.)

Safety Information

• Storage Condition: Refrigerator
• Storage Warning: Irritant

DETAILS

Toronto Research Chemicals - P480500

Metabolite of Prazosin. It is also an impurity arising in the synthesis of Terazosin (T105000).

REFERENCES

• Bolognesi, M., et al.: J. Med. Chem., 44, 362 (2001)
• Shaw, Y., et al.: J. Med. Chem., 47, 4453 (2001)
• Erve, J., et al.: Drug Metab. Disposition, 35, 908 (2001)
• Cavalli, A., et al.: Bioorg. Med. Chem. Lett., 19, 3031 (2001)