chloro({[chlorobis(propan-2-yl)silyl]oxy})bis(propan-2-yl)silane

• ChemBase ID: 76130
• Molecular Formular: C12H28Cl2OSi2
• Molecular Mass: 315.42712
• Monoisotopic Mass: 314.10557394
• SMILES: O([Si](C(C)C)(C(C)C)Cl)[Si](Cl)(C(C)C)C(C)C
• Canonical SMILES: CC([Si](C(C)C)(O[Si](C(C)C)(C(C)C)Cl)Cl)C
• InChI: InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3
• InChIKey: DDYAZDRFUVZBMM-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: chloro({[chlorobis(propan-2-yl)silyl]oxy})bis(propan-2-yl)silane
• IUPAC Traditional name: chloro[(chlorodiisopropylsilyl)oxy]diisopropylsilane
• Synonyms: TIPDSiCl2; 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane; 1,3-Dichloro-1,1,3,3-tetrakis(prop-2-yl)disiloxane; 1,3-Dichloro-1,1,3,3-tetrakis(isopropyl)disiloxane; 1,3-DICHLORO-1,1,3,3-TETRA-ISOPROPYL-1,3-DISILOXANE; 1,3-二氯-1,1,3,3-四异丙基二硅氧烷

Database IDs

• CAS Number: 69304-37-6
• EC Number: 000-000-0
• MDL Number: MFCD00009655
• Beilstein Number: 1934216
• PubChem SID: 162041045; 24862477; 24860447; 24862491
• PubChem CID: 172404

CALCULATED PROPERTIES

• H Acceptors: 1
• H Donor: 0
• LogD (pH = 5.5): 4.9202
• LogD (pH = 7.4): 4.9202
• Log P: 4.9202
• Molar Refractivity: 73.4112 cm^3
• Polarizability: 33.049164 Å^3
• Polar Surface Area: 9.23 Å^2
• Rotatable Bonds: 6
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Boiling Point: 69-70°C/0.5mm; 70 °C/0.5 mmHg(lit.); 70°C/0.5mm
• Flash Point: >110°C(230°F); 110 °C; 110°C; 113 °C; 230 °F; 235.4 °F
• Density: 0.986; 0.986 g/mL at 25 °C(lit.); 1.0 g/ml
• Refractive Index: 1.4540; n20/D 1.454(lit.); n20/D 1.455

Safety Information

• Storage Warning: Corrosive/Moisture Sensitive/Keep Cold/Store under Argon; Moisture Sensitive
• European Hazard Symbols: Corrosive (C)
• UN Number: 3265; UN1760
• German water hazard class: 3
• Hazard Class: 8
• Packing Group: 2; II
• Risk Statements: 34
• Safety Statements: 20-26-36/37/39-45; 26-27-28-36/37/39-45
• TSCA Listed: 否
• GHS Pictograms: GHS05
• GHS Signal Word: Danger
• GHS Hazard statements: H314; H314-H318
• GHS Precautionary statements: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A; P280-P305 + P351 + P338-P310
• Personal Protective Equipment: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 3265 8/PG 2
• Storage Temperature: 2-8°C

Product Information

• Purity: ≥90%; ≥97.0% (GC); ≥98.5% (GC); 90%; 97%
• Grade: puriss.; purum
• Linear Formula: [(CH3)2CH]2Si(Cl)OSi(Cl)[CH(CH3)2]2

DETAILS

MP Biomedicals - 02157657

Purity: 90%
1 ml = approx. 1.0 g

Sigma Aldrich - 337005

Packaging
1, 5 g in glass bottle

Sigma Aldrich - 36520

Other Notes
Reagent for the simultaneous protection of 3′- and 5′-hydroxy functions of nucleosides 1,2; Protecting group reagent for carbohydrates 3,4

REFERENCES

• Reagent for the protection of diols, including carbohydrate-type molecules, as their 1,3-(1,1,3,3-tetraisopropyldisiloxanylidene) (TIPDS) derivatives, formed in the presence of imidazole: J. Chem. Res. Synop., 24 (1979); J. Org. Chem., 50, 1651 (1985), or pyridine-DMF: Tetrahedron, 41, 4545, 4557 (1985). The high steric demand of the TIPDS group enables discrimination between primary and secondary OH. It is readily cleaved by F^- (e.g. TBAF in THF) or by aqueous acid or base. See Appendix 4.