4-chloronaphthalen-1-ol

• ChemBase ID: 75375
• Molecular Formular: C10H7ClO
• Molecular Mass: 178.61498
• Monoisotopic Mass: 178.01854252
• SMILES: Oc1c2ccccc2c(cc1)Cl
• Canonical SMILES: Clc1ccc(c2c1cccc2)O
• InChI: InChI=1S/C10H7ClO/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,12H
• InChIKey: LVSPDZAGCBEQAV-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 4-chloronaphthalen-1-ol
• IUPAC Traditional name: 4-chloro-1-naphthol
• Synonyms: 4-Chloro-1-hydroxynaphthalene; 4-Chloro-1-naphthol; 4-Chloro-1-naphthol; 4-Chloro-1-naphthol solution; 4-chloronaphthalen-1-ol; 4-氯-1-萘酚; 4-氯-1-萘酚 溶液

Database IDs

• CAS Number: 604-44-4
• EC Number: 210-068-5
• MDL Number: MFCD00003974
• Beilstein Number: 509750
• PubChem SID: 24855304; 24892896; 162040293; 24893113; 24893047
• PubChem CID: 11787

CALCULATED PROPERTIES

• Acid pKa: 8.607161
• H Acceptors: 1
• H Donor: 1
• LogD (pH = 5.5): 3.2628648
• LogD (pH = 7.4): 3.2372231
• Log P: 3.263202
• Molar Refractivity: 49.2939 cm^3
• Polarizability: 20.319906 Å^3
• Polar Surface Area: 20.23 Å^2
• Rotatable Bonds: 0
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: methanol: soluble50 mg/mL, clear, colorless to very faintly yellow
• Apperance: crystalline; tablet
• Melting Point: 118-120 °C; 118-121 °C(lit.); 120 - 121°C; 120-121°C
• Flash Point: 163.4 °F; 73 °C
• Hydrophobicity(logP): 3.659
• Fluorescence: λex 310 nm; λem 375 nm in ethanol

Safety Information

• Storage Condition: 0°C; 2-8°C
• Storage Warning: Irritant/Light Sensitive/Store under Argon
• European Hazard Symbols: Toxic (T); Irritant (Xi)
• UN Number: 2810
• German water hazard class: 1; 3
• Hazard Class: 6.1
• Packing Group: 3
• Risk Statements: 20/21/22-39/23/24/25; 36/37/38; R:36/37/38
• Safety Statements: 26-36; 36/37; S:20-25-26-37/39
• GHS Pictograms: GHS07; GHS08
• GHS Signal Word: Danger; Warning
• GHS Hazard statements: H302-H312-H332-H370; H315-H319-H335
• GHS Precautionary statements: P260-P280-P307 + P311; P261-P305 + P351 + P338
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves; Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 2810 6.1/PG 3
• Storage Temperature: -20°C; 2-8°C

Product Information

• Purity: ≥99.0%; ≥99.0% (HPLC); 95%; 95+%; 97%; 99%
• Grade: for analytical purposes
• Linear Formula: ClC10H6OH

DETAILS

MP Biomedicals - 05215236

MP Biomedicals Rare Chemical collection

MP Biomedicals - 02152347

Stabilized Chromogen Chromogen solution for immunohistology procedures and peroxidase and pseudo-peroxidase reactions. Ready-to-use directly as the final step in developing the color indicator in the enzyme reaction. Precipitates as a readily detected marker for immunohistopathological staining. Stable up to 15 months.

MP Biomedicals - 02150629

Purity: 97%
Off-white to tan crystals.

Sigma Aldrich - C6788

Quantity
Contains 30 mg substrate per tablet.
Reconstitution
Dissolve 1 tablet in 10 ml of methanol. Add 2 ml of methanol stock solution to 10 ml of triethanolamine buffered saline, pH 7.5. Add 5 μl of fresh 30% hydrogen peroxide (Sigma Product No. H-1009) immediately prior to use.
Specificity
4-Chloro-1-Naphthol is a peroxidase substrate suitable for use in immunoblotting procedures. This substrate produces an insoluble end product that is blue in color and can be observed visually.

Sigma Aldrich - C8302

Other Notes
0.48 mM 4-chloro-1-naphthol, 50 mM Tris-HCl, 0.2 M NaCl and 17% methanol.
Substrates
Substrate for visualizing peroxidase conjugates in Western blotting.

Sigma Aldrich - C8890

Packaging
2.5, 5, 25, 100 g in glass bottle
Substrates
Chromogenic peroxidase substrate useful in enzyme-linked detection procedures.

Sigma Aldrich - 317403

Application
Peroxidase stain.1

Sigma Aldrich - 25328

Application
electrophoresis test: suitable for peroxidase detection on blotting membranes
Other Notes
Peroxidase stain. In the detection of specific antigens after isoelectric focusing and immunoblotting into nitrocellulose membranes1; In a dot-immunobinding assay for the detection and quantitation of human IgE2; A rapid multicolor Western blot3

Sigma Aldrich - C57804

Packaging
25 g in glass bottle

REFERENCES

• Jarrell, K.F., et al., Molecular Microbiology , 20(3) : 657 (1996).