(1S,2S,4R,7S,10R,11S,14S,15S)-2,4,15-trimethyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl propanoate

• ChemBase ID: 736
• Molecular Formular: C23H36O3
• Molecular Mass: 360.53014
• Monoisotopic Mass: 360.26644501
• SMILES: O([C@@H]1[C@@]2([C@H]([C@H]3[C@@H]([C@@]4([C@@H](CC3)CC(=O)[C@@H](C4)C)C)CC2)CC1)C)C(=O)CC
• Canonical SMILES: CCC(=O)O[C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)C[C@@H](C)C(=O)C2
• InChI: InChI=1S/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/m1/s1
• InChIKey: NOTIQUSPUUHHEH-UXOVVSIBSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (1S,2S,4R,7S,10R,11S,14S,15S)-2,4,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecan-14-yl propanoate; (1S,2S,4R,7S,10R,11S,14S,15S)-2,4,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl propanoate
• IUPAC Traditional name: masteron; dromostanolone
• Brand Name: Drolban; Emdisterone; Masterid; Masteril; Masteron; Masterone; Metholone; Permastril
• Synonyms: Drostanolone propionate; 2M-DHTP; 2MDTP; MDHT; Medrotestron propionate; Dromostanolone propionate; Dromostanolone proprionate; Drostanolone; Drostanolone propionate; Blackburn Compound; Dromostanolone; (1S,2S,4R,7S,10R,11S,14S,15S)-2,4,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl propanoate

Database IDs

• CAS Number: 58-19-5
• MDL Number: MFCD01669961
• PubChem SID: 160964199
• PubChem CID: 224004
• CHEBI ID: 31523
• Chemspider ID: 194604
• DrugBank ID: DB00858
• Wikipedia Title: Drostanolone_propionate

CALCULATED PROPERTIES

JChem

• H Acceptors: 2
• H Donor: 0
• LogD (pH = 5.5): 5.0959053
• LogD (pH = 7.4): 5.0959053
• Log P: 5.0959053
• Molar Refractivity: 101.956 cm^3
• Polarizability: 41.01097 Å^3
• Polar Surface Area: 43.37 Å^2
• Rotatable Bonds: 3
• Lipinski's Rule of Five: false

ALOGPS 2.1

• Log P: 4.76
• LOG S: -5.76
• Solubility (Water): 6.29e-04 g/l

PROPERTIES

Physical Property

• Hydrophobicity(logP): 5.547; 5.8

Pharmacology Properties

• Admin Routes: Intramuscular injection or transdermal cream
• Bioavailability: Oral 0-2%, Intramuscular 100%
• Excretion: renal
• Half Life: 2-3 Days
• Metabolism: hepatic
• Protein Bound: highly
• Legal Status: Schedule III (US); Schedule IV (Canada)
• Pregnancy Category: X

Product Information

• Purity: 95%

DETAILS

DrugBank - DB00858

• Drug Groups: illicit; approved
• Description: Drostanolone (also known as dromostanolone) is a potent synthetic androgenic anabolic steroid similar to testosterone. Drostanolone is indicated in postmenopausal women with recurrent breast cancer, in a combined hormone therapy.
• Indication: For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
• Pharmacology: Dromostanolone is a synthetic androgen, or male hormone, similar to testosterone. Dromostanolone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
• Toxicity: Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.
• Affected Organisms: Humans and other mammals
• Absorption: Well absorbed following parenteral administration.
• External Links: Wikipedia