5,5-diphenyl-2-(sodiooxy)-4,5-dihydro-1H-imidazol-4-one

• ChemBase ID: 73062
• Molecular Formular: C15H11N2NaO2
• Molecular Mass: 274.24981
• Monoisotopic Mass: 274.07182188
• SMILES: N1C(C(=O)N=C1O[Na])(c1ccccc1)c1ccccc1
• Canonical SMILES: [Na]OC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1
• InChI: InChI=1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
• InChIKey: FJPYVLNWWICYDW-UHFFFAOYSA-M

NAMES AND DATABASE IDS

Names

• IUPAC name: 5,5-diphenyl-2-(sodiooxy)-4,5-dihydro-1H-imidazol-4-one
• IUPAC Traditional name: 5,5-diphenyl-2-(sodiooxy)-1H-imidazol-4-one
• Synonyms: Aleviatin; Diphenylhydantoin sodium; Eptoin;; Phenytoin sodium

Database IDs

• CAS Number: 630-93-3
• PubChem SID: 162037982
• PubChem CID: 23679632

CALCULATED PROPERTIES

• H Acceptors: 4
• H Donor: 1
• LogD (pH = 5.5): 3.7595
• LogD (pH = 7.4): 3.7595
• Log P: 3.7595
• Molar Refractivity: 69.2896 cm^3
• Polarizability: 28.979593 Å^3
• Polar Surface Area: 50.69 Å^2
• Rotatable Bonds: 3
• Lipinski's Rule of Five: true

PROPERTIES

Safety Information

• Storage Condition: -20°C

Product Information

• Salt Data: sodium salt

DETAILS

Selleck Chemicals - S2524

Research Area: Neurological Disease
Biological Activity:
Phenytoin sodium (Dilantin) is an inactive voltage-gated sodium channel stabilizer. Phenytoin sodium is a commonly used antiepileptic. Phenytoin blocks voltage-dependent sodium channels to inhibit propagation from active electrical foci, an effect more useful for nontoxicological seizures. Phenytoin sodium (Dilantin) acts to suppress the abnormal brain activity seen in seizure by reducing electrical conductance among brain cells. Aside from seizures, Phenytoin sodium (Dilantin) is an option in the treatment of trigeminal neuralgia in the event that carbamazepine or other 1st line treatment is deemed inappropriate. [1][2]

REFERENCES

• Shah AS et al. Clin Toxicol (Phila). 2010 Oct;48