NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium bromide
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IUPAC Traditional name
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Synonyms
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Prostigmin
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Vagostigmin
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Neostigmine bromide
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(m-Hydroxyphenyl)trimethylammonium Bromide Dimethylcarbamate
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(3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide
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Eustigmin Bromide
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Kirkstigmine Bromide
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Neoeserine Bromide
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Neoesserin
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Philostigmin Bromide
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Prostigmin Bromide
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Prostigmine Bromide
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Stigmanol Bromide
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Stigmosan Bromide
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Syntostigmin
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Syntostigmin Bromide
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Vagostigmine
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3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzenaminium bromide
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Prostigmine
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NEOSTIGIMINE BROMIDE
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3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide
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Neostigmine bromide
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CAS Number
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EC Number
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MDL Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
H Acceptors
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1
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H Donor
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0
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LogD (pH = 5.5)
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-2.2459824
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LogD (pH = 7.4)
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-2.2459824
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Log P
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-2.2459824
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Molar Refractivity
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75.2818 cm3
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Polarizability
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24.687561 Å3
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Polar Surface Area
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29.54 Å2
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Rotatable Bonds
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3
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Lipinski's Rule of Five
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true
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DETAILS
DETAILS
MP Biomedicals
Selleck Chemicals
Sigma Aldrich
TRC
Selleck Chemicals -
S2490
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Research Area: Neurological Disease Biological Activity: Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It binds to the anionic site of cholinesterase. The drug blocks the active site of acetylcholinesterase so the enzyme can no longer break down the acetylcholine molecules before they reach the postsynaptic membrane receptors. This allows for the threshold to be reached so a new impulse can be triggered in the next neuron. In myasthenia gravis there are too few acetylcholine receptors so with the acetylcholinesterase blocked, acetylcholine can bind to the few receptors and trigger a muscular contraction. [1]References on Neostigmine bromide (Prostigmin)[1] http://en.wikipedia.org/wiki/Neostigmine, , |
Sigma Aldrich -
N2001
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Biochem/physiol Actions Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier. |
PATENTS
PATENTS
PubChem Patent
Google Patent