NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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(2R)-2-amino-3-[(3-hydroxypropyl)sulfanyl]propanoic acid
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IUPAC Traditional name
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Synonyms
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Fudosteine
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3-[(3-Hydroxypropyl)thio]alanine
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(-)-3-[(3-Hydroxypropyl)thio]-L-alanine
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Cleanal
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Fudosteine
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SS 320A
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Spelear
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S-(3-Hydroxypropyl)-L-cysteine
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CAS Number
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MDL Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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2.3556938
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H Acceptors
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4
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H Donor
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3
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LogD (pH = 5.5)
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-3.1388693
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LogD (pH = 7.4)
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-3.1458898
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Log P
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-3.1388948
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Molar Refractivity
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44.0815 cm3
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Polarizability
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17.567696 Å3
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Polar Surface Area
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83.55 Å2
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Rotatable Bonds
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6
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Lipinski's Rule of Five
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true
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DETAILS
DETAILS
Selleck Chemicals
TRC
Selleck Chemicals -
S2129
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Research Area: Respiratory Diseases Biological Activity: Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. MUC5AC mucin synthesis and the expression of the MUC5AC gene were increased by LPS in rats or TNF-α in NCI-H292 cells; these effects were inhibited by fudosteine treatment. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. [1] |
REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • Antonela Antoniu S. Expert Opin Investig Drugs
- • Takeyama, K., et al.: J. Immunol.,164, 1546 (2000)
- • Komatsu, H., et al.: Pulm. Pharmacol. Ther., 18, 121 (2000)
- • Rhee, C., et al.: Eur. Respir. J., 32, 1195 (2000)
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PATENTS
PATENTS
PubChem Patent
Google Patent