NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
|
6-(benzyloxy)-9H-purin-2-amine
|
6-(benzyloxy)-7H-purin-2-amine
|
|
|
IUPAC Traditional name
|
6-(benzyloxy)-9H-purin-2-amine
|
6-(benzyloxy)-7H-purin-2-amine
|
|
|
Synonyms
|
6-(Benzyloxy)-7H-purin-2-amine
|
6-(Phenylmethoxy)-9H-purin-2-amine
|
2-Amino-6-(benzyloxy)purine
|
NSC 637037
|
O6-Benzylguanine
|
6-(Benzyloxy)-9H-purin-2-amine
|
O(6)-Benzylguanine
|
6-(Benzyloxy)guanine
|
6-O-Benzylguanine
|
O(6)-bGua
|
O6-BG
|
O6-Benzylguanine
|
|
|
CAS Number
|
|
MDL Number
|
|
PubChem SID
|
|
PubChem CID
|
|
Chemspider ID
|
|
Wikipedia Title
|
|
DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
|
10.196849
|
H Acceptors
|
5
|
H Donor
|
2
|
LogD (pH = 5.5)
|
1.6720533
|
LogD (pH = 7.4)
|
1.6714947
|
Log P
|
1.6721176
|
Molar Refractivity
|
69.2413 cm3
|
Polarizability
|
25.45866 Å3
|
Polar Surface Area
|
89.71 Å2
|
Rotatable Bonds
|
3
|
Lipinski's Rule of Five
|
true
|
DETAILS
DETAILS
Apollo Scientific
Wikipedia
Sigma Aldrich
TRC
Apollo Scientific Ltd -
OR7851T
|
An effective substrate & efficient inactivator of DNA alkyl transferase. Protects against carcinogenic & therapeutic alkylating agents. |
Sigma Aldrich -
B2292
|
Biochem/physiol Actions O(6)-benzylguanine is an antineoplastic agent that binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), resulting in inhibition of AGT-mediated DNA repair. It is widely used in various DNA repair mechanism studies and potentiates the effects of other chemotherapeutic agents that damage DNA. |
Toronto Research Chemicals -
B278500
|
An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents. |
REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • Dolan, M.E., et al.: Proc. Natl. Acad. Sci. USA, 87, 5356 (1990)
- • Goodtzova, K., et al.: Biochemistry, 33, 385 (1990)
- • Elder, R.H., et al.: Biochem. J., 298, 231 (1994)
- Searching...Please wait...
PATENTS
PATENTS
PubChem Patent
Google Patent