(2S)-2,5-diaminopentanoic acid hydrochloride

• ChemBase ID: 69818
• Molecular Formular: C5H13ClN2O2
• Molecular Mass: 168.62192
• Monoisotopic Mass: 168.06655535
• SMILES: C(=O)([C@@H](N)CCCN)O.Cl
• Canonical SMILES: N[C@H](C(=O)O)CCCN.Cl
• InChI: InChI=1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
• InChIKey: GGTYBZJRPHEQDG-WCCKRBBISA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (2S)-2,5-diaminopentanoic acid hydrochloride
• IUPAC Traditional name: ornithine hydrochloride
• Synonyms: (S)-2,5-Diaminopentanoic Acid Hydrochloride; L-(+)-Ornithine Monohydrochloride; (S)-α,δ-Diaminovaleric Acid; 5-Amino-L-norvaline; L-Ornithine monohydrochloride; L-2,5-Diaminopentanoic acid; (S)-(+)-2,5-Diaminopentanoic acid hydrochloride; (S)-2,5-Diaminopentanoic acid monohydrochloride; L-Ornithine monohydrochloride; L-Ornithine hydrochloride; L-Ornithine hydrochloride; H-Orn-OH.HCl; (S)-2,5-二氨基戊酸 单盐酸盐; L-鸟氨酸 单盐酸盐; (S)-(+)-2,5-二氨基戊酸 盐酸盐; L-鸟氨酸 单盐酸盐; L-鸟氨酸 盐酸盐; L-鸟氨酸盐酸盐

Database IDs

• CAS Number: 3184-13-2
• EC Number: 221-678-6
• MDL Number: MFCD00064562
• Beilstein Number: 3625847
• Merck Index: 146874
• PubChem SID: 24897960; 24898036; 24886830; 162035543; 24897996
• PubChem CID: 76654
• FEMA ID: 4190

CALCULATED PROPERTIES

• Acid pKa: 2.6664226
• H Acceptors: 4
• H Donor: 3
• LogD (pH = 5.5): -6.399376
• LogD (pH = 7.4): -5.4160175
• Log P: -3.6582875
• Molar Refractivity: 33.2085 cm^3
• Polarizability: 13.533871 Å^3
• Polar Surface Area: 89.34 Å^2
• Rotatable Bonds: 4
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: H2O: soluble1 M at 20 °C, clear, colorless; H2O: soluble1 M at 20 °C, clear, faintly yellow; Water
• Apperance: White Solid
• Melting Point: 233°C (dec.); 239-241°C; 245 °C (dec.)(lit.); ca 238°C dec.
• Optical Rotation: [α]20/D +23.0±0.5°, c = 5% in 5 M HCl; [α]24/D +23.6°, c = 4 in 6 M HCl; +23 (c=5 in 5N HCl)
• Absorption Wavelength: λ: 260 nm Amax: 0.06; λ: 280 nm Amax: 0.06
• pH: 5.0-6.0 (25 °C, 1 M in H2O)

Safety Information

• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere; Room Temperature (15-30°C)
• Storage Warning: IRRITANT
• RTECS: RM2985000
• European Hazard Symbols: Irritant (Xi)
• German water hazard class: 2
• Risk Statements: 36
• Safety Statements: 26
• TSCA Listed: false; 是
• GHS Pictograms: GHS07
• GHS Signal Word: Warning
• GHS Hazard statements: H319
• GHS Precautionary statements: P305 + P351 + P338
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Pharmacology Properties

• Allergens: no known allergens

Product Information

• Purity: ~99%; ≥99%; ≥99.0% (AT); ≥99.5% (AT); 95+%; 99%
• Suitability: suitable for cell culture
• Ignition Residue: ≤0.1%; ≤0.1% (as SO4)
• Impurities: ≤0.005% Phosphorus (P); ≤0.1% Insoluble matter; ≤0.3% foreign amino acids; ammonia and citrulline, essentially free; ammonia- and citrulline-free, essentially free; insoluble matter, passes filter test
• Cation Traces: Al: ≤0.0005%; Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤0.005%; Ca: ≤10 mg/kg; Ca: ≤60 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤0.0005%; Cu: ≤5 mg/kg; Fe: ≤0.0005%; Fe: ≤5 mg/kg; K: ≤0.005%; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤0.0005%; Mg: ≤10 mg/kg; Mg: ≤5 mg/kg; Mn: ≤10 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤0.005%; Na: ≤50 mg/kg; NH4+: ≤0.05%; NH4+: ≤100 mg/kg; NH4+: ≤200 mg/kg; Ni: ≤5 mg/kg; Pb: ≤0.001%; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤0.0005%; Zn: ≤5 mg/kg
• Antion Traces: sulfate (SO42-): ≤0.05%; sulfate (SO42-): ≤100 mg/kg; sulfate (SO42-): ≤50 mg/kg
• Loss on Drying: ≤0.1% loss on drying, 20 °C (HV); ≤0.5% loss on drying, 110 °C
• λ: 1 M in H2O
• Product Line: BioXtra
• Linear Formula: NH2(CH2)3CH(CO2H)(NH2) · HCl
• Empirical Formula (Hill Notation): C5H12N2O2 · HCl

DETAILS

MP Biomedicals - 02194718

Cell Culture Reagent
Hydrochloride
Crystalline
Purity: ~99%
This material is essentially free of citrulline and ammonia.

MP Biomedicals - 02100421

Hydrochloride
Crystalline
Purity: ~99%
This material is essentially free of citrulline and ammonia.

Sigma Aldrich - O6503

Other Notes
精氨酸通过精氨酸酶降解所得产物
Application
Use as a media supplement to support the biosynthesis of polyamines.
General description
L-Ornithine is an amino acid that is not coded for by the genetic code. It is formed during the decomposition of argininine by arginase and participates in the urea cycle. Ornithine is the starting point for the formation of a family of polyamines that include spermine, spermidine and putrescine.

Sigma Aldrich - O2375

Other Notes
精氨酸通过精氨酸酶降解所得产物
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. O2375.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
包装
1 kg in poly bottle
10 mg in autosmp vl
5, 25, 100 g in poly bottle
Biochem/physiol Actions
L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle.

Sigma Aldrich - 75469

Other Notes
Product of arginine degradation by arginase

Sigma Aldrich - O4386

Other Notes
精氨酸通过精氨酸酶降解所得产物
Biochem/physiol Actions
L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle.

Sigma Aldrich - W419001

Packaging
1 kg in poly bottle
1 sample in glass bottle
100 g in poly bottle

Sigma Aldrich - O8305

Packaging
25 g in poly bottle

Sigma Aldrich - 75470

Other Notes
Product of arginine degradation by arginase

Toronto Research Chemicals - O695550

L-Ornithine is a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chick

REFERENCES

• Fattori, D., et al.: J. Med. Chem., 50, 550 (2007)
• Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007)
• Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2007)