NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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2-benzyl-4,5-dihydro-1H-imidazole
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IUPAC Traditional name
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Brand Name
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Artonil
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Benzazoline
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Benzidazol
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Benzolin
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Benzylimidazoline
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Dilatol Asi
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Divascol
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Imidalin
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Imidaline
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Kasimid
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Lambril
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Olitensol
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Peripherine
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Phenylmethylimidazoline
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Prefaxil
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Priscol
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Priscoline
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Tolazolin
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Vasimid
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Vasodil
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Vasodilatan
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Synonyms
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Tolazoline
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2-BENZYL-4,5-IMIDAZOLINE HYDROCHLORIDE
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4,5-dihydro-2-(phenylmethyl)-1h-imidazole
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Benzidazol
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NSC 35110
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Phenylmethylimidazoline
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2-Benzyl-2-imidazoline
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2-Benzyl-4,5-dihydro-1H-imidazole
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Tolazoline
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2-Benzylimidazoline
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2-苄基-2-咪唑啉
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2-苄基-4,5-二氢-1H-咪唑
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托拉佐林
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2-苯甲基咪唑啉
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CAS Number
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EC Number
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MDL Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
ALOGPS 2.1
H Acceptors
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2
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H Donor
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1
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LogD (pH = 5.5)
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-1.20981
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LogD (pH = 7.4)
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-1.0758278
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Log P
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1.2036402
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Molar Refractivity
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49.0693 cm3
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Polarizability
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18.839672 Å3
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Polar Surface Area
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24.39 Å2
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Rotatable Bonds
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2
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Lipinski's Rule of Five
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true
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Log P
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2.05
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LOG S
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-2.07
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Solubility (Water)
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1.36e+00 g/l
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DETAILS
DETAILS
MP Biomedicals
DrugBank
Sigma Aldrich
DrugBank -
DB00797
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Item |
Information |
Drug Groups
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approved |
Description
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A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. [PubChem] |
Indication |
For the treatment of pulmonary artery anomalies |
Pharmacology |
Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN). |
Affected Organisms |
• |
Humans and other mammals |
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External Links |
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Sigma Aldrich -
293490
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Packaging 1, 5 g in glass bottle Application Reactant for synthesis of imidazoline-containing drug1 Other Notes Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 293490.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. |
PATENTS
PATENTS
PubChem Patent
Google Patent