N-(5-aminopentyl)-N-hydroxy-N'-[5-(N-hydroxy-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propanamido)pentyl]butanediamide

• ChemBase ID: 626
• Molecular Formular: C25H48N6O8
• Molecular Mass: 560.68402
• Monoisotopic Mass: 560.35336253
• SMILES: ON(CCCCCNC(=O)CCC(=O)N(O)CCCCCN)C(=O)CCC(=O)NCCCCCN(O)C(=O)C
• Canonical SMILES: NCCCCCN(C(=O)CCC(=O)NCCCCCN(C(=O)CCC(=O)NCCCCCN(C(=O)C)O)O)O
• InChI: InChI=1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)
• InChIKey: UBQYURCVBFRUQT-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: N-(5-aminopentyl)-N-hydroxy-N'-[5-(N-hydroxy-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propanamido)pentyl]butanediamide
• IUPAC Traditional name: deferoxamine
• Brand Name: Desferal; Desferan; Desferex; Desferin; Desferral; Desferrin
• Synonyms: Deferoxamine mesylate; Deferoxaminum; Deferrioxamine; Deferoxamin; DFO; N-Benzoylferrioxamine B; DF B; DFOA; DFOM; Desferrioxamine; Desferrioxamine B; Deferrioxamine B; Deferoxamide B; Deferoxamine B; Deferoxamine; N'-[5-(Acetyl-hydroxy-amino)pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino]pentyl]-N-hydroxy-butane diamide

Database IDs

• CAS Number: 70-51-9
• Beilstein Number: 2514118
• PubChem SID: 160964089; 46506395
• PubChem CID: 2973
• CHEBI ID: 4356
• ATC CODE: V03AC01
• CHEMBL: 556
• Chemspider ID: 2867
• DrugBank ID: DB00746
• KEGG ID: D03670
• Unique Ingredient Identifier: J06Y7MXW4D
• Wikipedia Title: Deferoxamine

CALCULATED PROPERTIES

JChem

• Acid pKa: 7.915494
• H Acceptors: 9
• H Donor: 6
• LogD (pH = 5.5): -4.9015827
• LogD (pH = 7.4): -3.638875
• Log P: -3.365162
• Molar Refractivity: 144.9508 cm^3
• Polarizability: 56.376564 Å^3
• Polar Surface Area: 205.84 Å^2
• Rotatable Bonds: 23
• Lipinski's Rule of Five: false

ALOGPS 2.1

• Log P: 0.93
• LOG S: -3.75
• Solubility (Water): 9.90e-02 g/l

PROPERTIES

Physical Property

• Solubility: 1.2 mg/mL (at 20°C, 1.2%)
• Partition Coefficient: -0.614
• Hydrophobicity(logP): -2.2
• pKa: 9.079
• pKb: 4.918

Pharmacology Properties

• Admin Routes: Intramuscular; Intraperitoneal; Intravenous; Oral; Subcutaneous
• Half Life: 6 hours

DETAILS

DrugBank - DB00746

• Drug Groups: approved
• Description: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form. [PubChem]
• Indication: Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.
• Pharmacology: Deferoxamine, otherwise known as desferrioxamine or desferal, is a chelating agent used to remove excess iron or aluminum from the body. It acts by binding free iron or aluminum in the bloodstream and enhancing its elimination in the urine. By removing excess iron or aluminum, the agent reduces the damage done to various organs and tissues, such as the liver.
• Toxicity: Intravenous LD₅₀ in mouse, rat, and rabbit is 340 mg/kg, 520 mg/kg, and 600 mg/kg, respectively. Subcutaneous LD₅₀ in mouse and rat is 1600 mg/kg and >1000 mg/kg, respectively. Oral LD₅₀ in mouse and rat is >3000 mg/kg and >1000 mg/kg, respectively. Nephrotoxicity, ototoxicity and retinal toxicity have been reported following long-term administration for chronic iron overload.
• Affected Organisms: Humans and other mammals
• Biotransformation: Deferoxamine is mainly metabolised in the plasma and hepatic metabolism is minimal. A number of metabolites have been isolated but not characterised. Some metabolites of deferoxamine, most notably the product of oxidative deamination, also chelate iron, and thus the antidotal effect of the drug appears unaffected by hepatic metabolism.
• Absorption: Deferoxamine is rapidly absorbed after intramuscular or subcutaneous administration, but only poorly absorbed from the gastrointestinal tract in the presence of intact mucosa.
• Half Life: Biphasic elimination pattern in healthy volunteers with a first rapid phase half life of 1 hour and a second slow phase half-life of 6 hours.
• Protein Binding: Less than 10% bound to serum proteins in vitro.
• Elimination: Deferoxamine mesylate is metabolized principally by plasma enzymes, but the pathways have not yet been defined. Some is also excreted in the feces via the bile.
• References: [Link]
• External Links: Wikipedia; Drugs.com

REFERENCES

• Link