(2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione

• ChemBase ID: 500
• Molecular Formular: C21H21ClN2O8
• Molecular Mass: 464.85304
• Monoisotopic Mass: 464.09864332
• SMILES: Clc1c2[C@@H](O)[C@H]3C[C@@H]4[C@](O)(C(=O)C3=C(O)c2c(O)cc1)C(=O)/C(=C(/O)\N)/C(=O)[C@H]4N(C)C
• Canonical SMILES: CN([C@@H]1C(=O)/C(=C(\O)/N)/C(=O)[C@@]2([C@H]1C[C@H]1C(=C(O)c3c([C@H]1O)c(Cl)ccc3O)C2=O)O)C
• InChI: InChI=1S/C21H21ClN2O8/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31/h3-4,6-7,14-15,25-27,31-32H,5,23H2,1-2H3/b20-13+/t6-,7-,14-,15-,21-/m0/s1
• InChIKey: HXPZLYXFFSKHJA-GNCUHUTISA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione
• IUPAC Traditional name: declomycin
• Brand Name: 6-Demethyl-7-chlorotetracycline; 6-Demethylchlorotetracycline; 7-Chloro-6-demethyltetracycline; Bioterciclin; Clortetrin; DMCT; DMCT (antibiotic); Declomycin; Deganol; Demeclociclina [INN-Spanish]; Demeclocycline HCL; Demeclocycline [USAN:BAN]; Demeclocycline hydrochloride; Demeclocyclinum [INN-Latin]; Demeclor; Demethylchlorotetracycline; Demethylchlortetracyclin; Demethylchlortetracycline; Demethylchlortetracycline hydrochloride; Demethylchlortetracyclinum; Demetraclin; Diuciclin; Elkamicina; Ledermycin; Ledermycin hydrochloride; Methylchlorotetracycline; Mexocine; Novotriclina; Perciclina; Sumaclina; Tri-demethylchlortetracycline
• Synonyms: Demeclocycline

Database IDs

• CAS Number: 127-33-3
• PubChem SID: 160963963
• PubChem CID: 54680690

CALCULATED PROPERTIES

JChem

• Acid pKa: 2.5488048
• H Acceptors: 10
• H Donor: 6
• LogD (pH = 5.5): -1.7889279
• LogD (pH = 7.4): -3.618874
• Log P: -1.8159283
• Molar Refractivity: 123.341 cm^3
• Polarizability: 43.40215 Å^3
• Polar Surface Area: 181.62 Å^2
• Rotatable Bonds: 1
• Lipinski's Rule of Five: false

ALOGPS 2.1

• Log P: -0.07
• LOG S: -2.94
• Solubility (Water): 5.30e-01 g/l

PROPERTIES

Physical Property

• Solubility: 1520 mg/L
• Hydrophobicity(logP): 0.2

DETAILS

DrugBank - DB00618

• Drug Groups: approved
• Description: A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. [PubChem]
• Indication: Used primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.
• Pharmacology: Demeclocycline is a tetracycline antibiotic active against the following microorganisms: Rickettsiae (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, tick fevers), Mycoplasma pneumoniae (PPLO, Eaton agent), agents of psittacosis and ornithosis, agents of lymphogranulomavenereum and granuloma inguinale, the spirochetal agent of relapsing fever (Borrelia recurrentis), Haemophilus ducreyi (chancroid), Yersinia pestis, Pasteurella pestis and Pasteurella tularensis, Bartonella bacilliformis, Bacteroides species, Vibrio comma and Vibrio fetus, and Brucella species (in conjunction with streptomycin). Demeclocycline inhibits cell growth by inhibiting translation. Demeclocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Demeclocycline is bacteriostatic (it impairs bacterial growth but does not kill bacteria directly). Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
• Toxicity: Oral, rat: LD₅₀ = 2372 mg/kg
• Affected Organisms: Enteric bacteria and other eubacteria
• Biotransformation: Hepatic
• Absorption: Tetracyclines are readily absorbed.
• Half Life: 10-17 hours
• Protein Binding: 41-50%
• Elimination: Demeclocycline hydrochloride, like other tetracyclines, is concentrated in the liver and excreted into the bile where it is found in much higher concentrations than in the blood. Following a single 150 mg dose of demeclocycline hydrochloride in normal volunteers, 44% (n = 8) was excreted in urine and 13% and 46%, respectively, were excreted in feces in two patients within 96 hours as active drug.
• Clearance: * Renal cl=35 mL/min/1.73 m2
• References: De Troyer A, Demanet JC: Correction of antidiuresis by demeclocycline. N Engl J Med. 1975 Oct 30;293(18):915-8. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

REFERENCES

• De Troyer A, Demanet JC: Correction of antidiuresis by demeclocycline. N Engl J Med. 1975 Oct 30;293(18):915-8. Pubmed