NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
|
15-ethyl-14-ethynyl-5-(hydroxyimino)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-ol
|
|
|
IUPAC Traditional name
|
15-ethyl-14-ethynyl-5-(hydroxyimino)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-ol
|
|
|
Brand Name
|
|
Synonyms
|
|
CAS Number
|
|
PubChem SID
|
|
PubChem CID
|
|
DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
Data Source
|
Data ID
|
Price
|
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
ALOGPS 2.1
Acid pKa
|
11.466128
|
H Acceptors
|
3
|
H Donor
|
2
|
LogD (pH = 5.5)
|
3.6694894
|
LogD (pH = 7.4)
|
3.6712167
|
Log P
|
3.6712763
|
Molar Refractivity
|
95.8472 cm3
|
Polarizability
|
37.191574 Å3
|
Polar Surface Area
|
52.82 Å2
|
Rotatable Bonds
|
1
|
Lipinski's Rule of Five
|
true
|
Log P
|
3.18
|
LOG S
|
-4.73
|
Solubility (Water)
|
6.05e-03 g/l
|
PROPERTIES
PROPERTIES
Bioassay(PubChem)
DETAILS
DETAILS
DrugBank
DrugBank -
DB06713
|
Item |
Information |
Drug Groups
|
approved |
Description
|
Norelgestromin is a drug used in contraception. Norelgestromin is the active progestin responsible for the progestational activity that occurs in women after application of ORTHO EVRA patch. |
Indication |
Norelgestromin is used for contraception and menopausal hormonal therapy. Norelgestromin may potentially be used in breast cancer treatment due to its inhibitory effect on estrone sulfatase . They convert sulfated steroid precursors to estrogen during pregnancy. |
Pharmacology |
Norelgestromin is used for contraception and menopausal hormonal therapy transdermally or in combination with ethinyl estradiol as a vaginal ring. Norelgestromin, in combination with ethinyl estradiol inhibits ovulation by suppressing gonadotropins. |
References |
• |
Goa KL, Warner GT, Easthope SE: Transdermal ethinylestradiol/norelgestromin: a review of its use in hormonal contraception. Treat Endocrinol. 2003;2(3):191-206.
[Pubmed]
|
• |
Henzl MR: Norgestimate. From the laboratory to three clinical indications. J Reprod Med. 2001 Jul;46(7):647-61.
[Pubmed]
|
• |
Abrams LS, Skee DM, Wong FA, Anderson NJ, Leese PT: Pharmacokinetics of norelgestromin and ethinyl estradiol from two consecutive contraceptive patches. J Clin Pharmacol. 2001 Nov;41(11):1232-7.
[Pubmed]
|
|
External Links |
|
|
PATENTS
PATENTS
PubChem Patent
Google Patent