NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
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IUPAC Traditional name
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Brand Name
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Otrivine
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Otriven
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Otrivin
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Otrix
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Synonyms
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Xylomethazoline
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Xylometazoline
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2-(4-tert-Butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole
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2-(4-tert-butyl-2,6-dimethylbenzyl)-4,5-dihydro-1h-imidazole
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CAS Number
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MDL Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
ALOGPS 2.1
H Acceptors
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2
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H Donor
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1
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LogD (pH = 5.5)
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1.3619118
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LogD (pH = 7.4)
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1.48564
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Log P
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3.7755392
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Molar Refractivity
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77.8176 cm3
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Polarizability
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29.674038 Å3
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Polar Surface Area
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24.39 Å2
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Rotatable Bonds
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3
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Lipinski's Rule of Five
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true
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Log P
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4.68
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LOG S
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-4.44
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Solubility (Water)
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8.93e-03 g/l
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DETAILS
DETAILS
DrugBank
DrugBank -
DB06694
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Item |
Information |
Drug Groups
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approved |
Description
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A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion. |
Indication |
It is used for treating nasal congestion and minor inflammation due to allergies or colds. |
Pharmacology |
Xylometazoline is a direct acting sympathomimetic adrenergic alpha-agonist used to induce systemic vasoconstriction, thereby decreasing nasal congestion. The sympathomimetic action of xylometazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (8-12 hours) decongesting effect. |
References |
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Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bonisch H: Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2009 Dec 17.
[Pubmed]
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External Links |
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PATENTS
PATENTS
PubChem Patent
Google Patent