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N-(6-carboxyhexyl)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-aminium chloride
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ChemBase ID:
4380
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Molecular Formular:
C22H28ClNO2
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Molecular Mass:
373.91622
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Monoisotopic Mass:
373.18085682
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SMILES and InChIs
SMILES:
[Cl-].OC(=O)CCCCCC[NH2+]C1c2c(CCc3c1cccc3)cccc2
Canonical SMILES:
OC(=O)CCCCCC[NH2+]C1c2ccccc2CCc2c1cccc2.[Cl-]
InChI:
InChI=1S/C22H27NO2.ClH/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);1H
InChIKey:
VDPUXONTAVMIKZ-UHFFFAOYSA-N
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Cite this record
CBID:4380 http://www.chembase.cn/molecule-4380.html
NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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N-(6-carboxyhexyl)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-aminium chloride
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IUPAC Traditional name
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N-(6-carboxyhexyl)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-aminium chloride
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Brand Name
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Synonyms
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Amineptine hydrochloride
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Amineptine
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CAS Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
Data Source
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Data ID
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Price
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CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
ALOGPS 2.1
Acid pKa
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4.41307
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H Acceptors
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2
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H Donor
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2
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LogD (pH = 5.5)
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2.717727
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LogD (pH = 7.4)
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2.742191
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Log P
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2.7436762
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Molar Refractivity
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112.6259 cm3
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Polarizability
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39.421856 Å3
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Polar Surface Area
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53.91 Å2
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Rotatable Bonds
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8
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Lipinski's Rule of Five
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true
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Log P
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0.99
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LOG S
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-7.31
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Solubility (Water)
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1.84e-05 g/l
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PROPERTIES
PROPERTIES
Bioassay(PubChem)
DETAILS
DETAILS
DrugBank
DrugBank -
DB04836
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Item |
Information |
Drug Groups
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illicit; withdrawn |
Description
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The Food and Drug Administration suspended the marketing authorisation for Survector in 1999 and France withdrew it from the market, however several developing countries continued to produce it up until 2005. |
Indication |
For the treatment of depression. |
Pharmacology |
Amineptine is an atypical tricyclic antidepressant. |
Affected Organisms |
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Humans and other mammals |
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Biotransformation |
Hepatic. |
Half Life |
48 minutes for the parent drug and 2.5 hours for the metabolites. |
References |
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Vaugeois JM, Corera AT, Deslandes A, Costentin J: Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor. Pharmacol Biochem Behav. 1999 Jun;63(2):285-90.
[Pubmed]
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Grupper C: [New iatrogenic acne: acne caused by amineptin (Survector)] Ann Dermatol Venereol. 1988;115(11):1174-6.
[Pubmed]
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Thioly-Bensoussan D, Charpentier A, Triller R, Thioly F, Blanchet P, Tricoire N, Noury JY, Grupper C: [Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases] Ann Dermatol Venereol. 1988;115(11):1177-80.
[Pubmed]
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Vexiau P, Gourmel B, Husson C, Castot A, Rybojad M, Julien R, Fiet J, Puissant A, Cathelineau G: [Severe lesions of acne type induced by chronic amineptin poisoning: apropos of 6 cases] Ann Dermatol Venereol. 1988;115(11):1180-2.
[Pubmed]
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Teillac D, Weber MJ, Lowenstein W, de Prost Y: [Acne caused by Survector] Ann Dermatol Venereol. 1988;115(11):1183-4.
[Pubmed]
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External Links |
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REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • Vaugeois JM, Corera AT, Deslandes A, Costentin J: Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor. Pharmacol Biochem Behav. 1999 Jun;63(2):285-90. Pubmed
- • Grupper C: [New iatrogenic acne: acne caused by amineptin (Survector)] Ann Dermatol Venereol. 1988;115(11):1174-6. Pubmed
- • Thioly-Bensoussan D, Charpentier A, Triller R, Thioly F, Blanchet P, Tricoire N, Noury JY, Grupper C: [Iatrogenic acne caused by amineptin (Survector). Apropos of 8 cases] Ann Dermatol Venereol. 1988;115(11):1177-80. Pubmed
- • Vexiau P, Gourmel B, Husson C, Castot A, Rybojad M, Julien R, Fiet J, Puissant A, Cathelineau G: [Severe lesions of acne type induced by chronic amineptin poisoning: apropos of 6 cases] Ann Dermatol Venereol. 1988;115(11):1180-2. Pubmed
- • Teillac D, Weber MJ, Lowenstein W, de Prost Y: [Acne caused by Survector] Ann Dermatol Venereol. 1988;115(11):1183-4. Pubmed
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PATENTS
PATENTS
PubChem Patent
Google Patent