NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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dimethyl({3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl})amine
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IUPAC Traditional name
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Brand Name
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Adazine
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Fluopromazine
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Psyquil
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Siquil
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Trifluopromazine
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Synonyms
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CAS Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
Data Source
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Data ID
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Price
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CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
ALOGPS 2.1
H Acceptors
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2
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H Donor
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0
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LogD (pH = 5.5)
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1.52148
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LogD (pH = 7.4)
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3.013445
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Log P
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4.808804
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Molar Refractivity
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94.9252 cm3
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Polarizability
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35.040066 Å3
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Polar Surface Area
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6.48 Å2
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Rotatable Bonds
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5
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Lipinski's Rule of Five
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true
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Log P
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4.95
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LOG S
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-5.29
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Solubility (Water)
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1.80e-03 g/l
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PROPERTIES
PROPERTIES
Physical Property
Bioassay(PubChem)
Hydrophobicity(logP)
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5.2
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Show
data source
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DETAILS
DETAILS
DrugBank
DrugBank -
DB00508
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Item |
Information |
Drug Groups
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approved |
Description
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A phenothiazine used as an antipsychotic agent and as an antiemetic. [PubChem] |
Indication |
Used mainly in the management of psychoses. Also used to control nausea and vomiting. |
Pharmacology |
Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspiciousness. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central nervous system. |
Toxicity |
Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness. |
Affected Organisms |
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Humans and other mammals |
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Biotransformation |
Hepatic. |
Absorption |
Absorption may be erratic and peak plasma concentrations show large interindividual differences. |
Protein Binding |
Very high (90% or more). |
External Links |
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PATENTS
PATENTS
PubChem Patent
Google Patent