[2-butyl-4-chloro-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol potassium hydride

• ChemBase ID: 312886
• Molecular Formular: C22H23ClKN6O
• Molecular Mass: 462.00892
• Monoisotopic Mass: 461.12589375
• SMILES: c1cc(ccc1c1c(cccc1)c1[nH]nnn1)Cn1c(c(nc1CCCC)Cl)CO.[K]
• Canonical SMILES: CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)CO)Cl.[K]
• InChI: InChI=1S/C22H23ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
• InChIKey: FDKIDFYIEWFERB-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: [2-butyl-4-chloro-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol potassium hydride
• IUPAC Traditional name: losartan potassium hydride
• Synonyms: Cozaar; Losartan potassium

Database IDs

• CAS Number: 124750-99-8

CALCULATED PROPERTIES

• Acid pKa: 4.288871
• H Acceptors: 5
• H Donor: 2
• LogD (pH = 5.5): 3.288697
• LogD (pH = 7.4): 2.8201647
• Log P: 3.9572647
• Molar Refractivity: 131.8496 cm^3
• Polarizability: 46.467342 Å^3
• Polar Surface Area: 92.51 Å^2
• Rotatable Bonds: 8
• Lipinski's Rule of Five: true

PROPERTIES

Pharmacology Properties

• Target: RAAS

Product Information

• Salt Data: Potassium