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1094-08-2 molecular structure
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diethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine

ChemBase ID: 275
Molecular Formular: C19H24N2S
Molecular Mass: 312.47226
Monoisotopic Mass: 312.16601978
SMILES and InChIs

SMILES:
S1c2c(N(CC(N(CC)CC)C)c3c1cccc3)cccc2
Canonical SMILES:
CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC
InChI:
InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
InChIKey:
CDOZDBSBBXSXLB-UHFFFAOYSA-N

Cite this record

CBID:275 http://www.chembase.cn/molecule-275.html

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NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
diethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine
IUPAC Traditional name
profenamine
Brand Name
Dibutil
Lysivane
Parcidol
Pardidol
Pardisol
Parfezin
Parfezine
Parkin
Parkisol
Parphezein
Parphezin
Parsidol
Parsitan
Parsotil
Prodictazin
Rochipel
Rocipel
Rodipal
Tomil
Parsidan
Synonyms
Ethopropazine Hydrochloride
Ethapropazine
Ethopromazine
Etopropezina
Aethopropropazin
Athapropazine
Athopropazin
Isothazine hydrochloride
Isothazine
Isotazin
Isopthazine
Fenpropazina
Isothiazine
Profenaminum [INN-Latin]
Profenamine monohydrochloride
Profenamine hydrochloride
Profenamine
Profenamina [Italian]
Profenamina [INN-Spanish]
Prophenamine
Prophenaminum
Prodierazine
Phenoprozine
Phenopropazine
Fempropazine
Ethopropazine
CAS Number
1094-08-2
PubChem SID
46507375
160963738
PubChem CID
3290

DATA SOURCES

DATA SOURCES

All Sources Commercial Sources Non-commercial Sources
Data Source Data ID
DrugBank DB00392 external link
PubChem 3290 external link
Data Source Data ID Price

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem ALOGPS 2.1
H Acceptors H Donor
LogD (pH = 5.5) 1.5971804  LogD (pH = 7.4) 2.8187735 
Log P 5.001187  Molar Refractivity 98.0021 cm3
Polarizability 37.847862 Å3 Polar Surface Area 6.48 Å2
Rotatable Bonds Lipinski's Rule of Five false 
Log P 5.75  LOG S -4.78 
Solubility (Water) 5.24e-03 g/l 

PROPERTIES

PROPERTIES

Physical Property Bioassay(PubChem)
Solubility
0.693 mg/L expand Show data source
Hydrophobicity(logP)
5.2 expand Show data source

DETAILS

DETAILS

DrugBank DrugBank
DrugBank - DB00392 external link
Item Information
Drug Groups approved
Description Ethopropazine (also known as profenamine hydrochloride) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat parkinsonism. It is sold under the trade names Parsidol in the United States and Parsidan in Canada.
Indication For use in the treatment of Parkinson's disease and also used to control severe reactions to certain medicines such as reserpine.
Pharmacology Ethopropazine, a phenothiazine and antidyskinetic, is used in the treatment of Parkinson's disease. By improving muscle control and reducing stiffness, this drug permits more normal movements of the body as the disease symptoms are reduced. It is also used to control severe reactions to certain medicines such as reserpine, phenothiazines, chlorprothixene, thiothixene, loxapine, and haloperidol. Unlike other NMDA antagonists, ethopropazine — because of its anticholinergic action — is largely devoid of neurotoxic side effects. Ethopropazine also has a slight antihistaminic and local anesthetic effect.
Toxicity Symptoms of overdose include severe clumsiness or unsteadiness, severe drowsiness, severe dryness of mouth, nose, or throat, fast heartbeat, shortness of breath or troubled breathing, and warmth, dryness, and flushing of skin.
Affected Organisms
Humans and other mammals
Absorption Well-absorbed from the gastrointestinal tract.
Half Life 1 to 2 hours
Protein Binding 93%
External Links
Wikipedia

REFERENCES

REFERENCES

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PATENTS

PATENTS

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