N,N-bis(2H3)methyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide

• ChemBase ID: 179661
• Molecular Formular: C19H21N3O
• Molecular Mass: 307.38954
• Monoisotopic Mass: 307.16846231
• SMILES: c1cc(cn2c1nc(c2CC(=O)N(C)C)c1ccc(cc1)C)C
• Canonical SMILES: Cc1ccc(cc1)c1nc2n(c1CC(=O)N(C)C)cc(cc2)C
• InChI: InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
• InChIKey: ZAFYATHCZYHLPB-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: N,N-bis(^2H₃)methyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
• IUPAC Traditional name: N,N-bis(^2H₃)methyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
• Synonyms: N,N,6-(Trimethyl-d6)-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide; N,N,6-(Trimethyl-d6)-2-p-tolylimidazol[1,2-a]pyridine-3-acetamide; SL 80-0750; SL 800750; Zolpidem-d6

Database IDs

• PubChem SID: 164235571
• PubChem CID: 45040706

CALCULATED PROPERTIES

• H Acceptors: 2
• H Donor: 0
• LogD (pH = 5.5): 2.6505303
• LogD (pH = 7.4): 3.0101333
• Log P: 3.0176268
• Molar Refractivity: 93.5837 cm^3
• Polarizability: 36.373756 Å^3
• Polar Surface Area: 37.61 Å^2
• Rotatable Bonds: 3
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: Chloroform
• Apperance: Off-White Solid
• Melting Point: 189-191°C

Safety Information

• Storage Condition: Controlled Substance, -20°C Freezer

DETAILS

Toronto Research Chemicals - Z650002

Deuterated Zolpidem, a selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant).

REFERENCES

• Arbilla, S., et al.: Arch. Pharmacol., 330, 248 (1985)
• Cashman, J.N., et al.: Brit. J. Clin. Pharmacol., 21, 205 (1986)