6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

• ChemBase ID: 179380
• Molecular Formular: C16H16FN3O3S
• Molecular Mass: 349.3799432
• Monoisotopic Mass: 349.08964061
• SMILES: n12c(c(c(=O)c3c1cc(c(c3)F)N1CCNCC1)C(=O)O)SC2C
• Canonical SMILES: Fc1cc2c(cc1N1CCNCC1)n1C(C)Sc1c(c2=O)C(=O)O
• InChI: InChI=1S/C16H16FN3O3S/c1-8-20-11-7-12(19-4-2-18-3-5-19)10(17)6-9(11)14(21)13(16(22)23)15(20)24-8/h6-8,18H,2-5H2,1H3,(H,22,23)
• InChIKey: SUXQDLLXIBLQHW-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
• IUPAC Traditional name: ulifloxacin
• Synonyms: 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic Acid; AF 3013; NAD 394; NM 394; Ulifloxacin

Database IDs

• CAS Number: 112984-60-8
• PubChem SID: 164235290
• PubChem CID: 124225

CALCULATED PROPERTIES

• Acid pKa: 5.944149
• H Acceptors: 6
• H Donor: 2
• LogD (pH = 5.5): -0.8388011
• LogD (pH = 7.4): -0.41008773
• Log P: -0.41674292
• Molar Refractivity: 100.7085 cm^3
• Polarizability: 33.529327 Å^3
• Polar Surface Area: 72.88 Å^2
• Rotatable Bonds: 2
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: DMSO
• Apperance: Yellow Solid
• Melting Point: >160°C (dec.)

Safety Information

• Storage Condition: Refrigerator

DETAILS

Toronto Research Chemicals - U700700

A metabolite of Prulifloxacin (P838885). Ulifloxacin is a new quinolone antibiotic and it is effective against pneumonia.

REFERENCES

• Kim, D., et al.: J. Pharm. Sci., 77, 200 (1988)
• Suzuki, T., et al.: Drug Metab. Dispos., 30, 1393 (1988)
• Sun, J., et al.: Eur. J. Pharm. Biopharm., 64, 238 (1988)