NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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sodium 3-[3-(tert-butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropanoate
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IUPAC Traditional name
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sodium 3-[3-(tert-butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate
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Synonyms
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1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)-1H-Indole-2-propanoic Acid Sodium Salt
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MK 591
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Quiflapon Sodium
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CAS Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
Data Source
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Data ID
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Price
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TRC
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CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
Acid pKa
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4.3153176
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H Acceptors
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4
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H Donor
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0
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LogD (pH = 5.5)
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7.504078
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LogD (pH = 7.4)
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5.7711735
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Log P
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8.505341
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Molar Refractivity
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178.4983 cm3
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Polarizability
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67.5369 Å3
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Polar Surface Area
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67.18 Å2
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Rotatable Bonds
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10
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Lipinski's Rule of Five
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false
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PROPERTIES
PROPERTIES
Safety Information
Product Information
Bioassay(PubChem)
DETAILS
DETAILS
TRC
Toronto Research Chemicals -
Q535400
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Quiflapon is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. Also, Quiflapon, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells. |
REFERENCES
REFERENCES
From Suppliers
Google Scholar
PubMed
Google Books
- • Carson, J., et al.: Cancer Res., 59, 1449 (1999)
- • Gupta, S., et al.: Cancer, 91, 737 (1999)
- • Jema, A., et al.: Cancer J. Clin., 57, 43 (1999)
- • Ochoa, J., et al.: Carcinogenesis, 25, 1185 (1999)
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PATENTS
PATENTS
PubChem Patent
Google Patent