N-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide

• ChemBase ID: 176849
• Molecular Formular: C14H22N2O3
• Molecular Mass: 266.33608
• Monoisotopic Mass: 266.16304257
• SMILES: c1c(ccc(c1)OCC(CNC(C)C)O)NC(=O)C
• Canonical SMILES: OC(COc1ccc(cc1)NC(=O)C)CNC(C)C
• InChI: InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
• InChIKey: DURULFYMVIFBIR-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: N-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide
• IUPAC Traditional name: practolol
• Synonyms: N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide; N-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide; (±)-Practolol; 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol; Dalzic; Eraldin; ICI 50172; DL-4'-[2-Hydroxy-3-(isopropylamino)propoxy]acetanilide; AY 21011; Teranol; 4'-[2-Hydroxy-3-(isopropylamino)propoxy]acetanilide; Racemic Practolol; dl-Practolol; rac Practolol

Database IDs

• CAS Number: 6673-35-4
• MDL Number: MFCD00864573
• PubChem SID: 164232759
• PubChem CID: 4883

CALCULATED PROPERTIES

• Acid pKa: 14.03433
• H Acceptors: 4
• H Donor: 3
• LogD (pH = 5.5): -2.3613021
• LogD (pH = 7.4): -1.3933091
• Log P: 0.83192956
• Molar Refractivity: 75.2385 cm^3
• Polarizability: 29.080378 Å^3
• Polar Surface Area: 70.59 Å^2
• Rotatable Bonds: 7
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Melting Point: 138 - 140°C
• Hydrophobicity(logP): 0.755

Product Information

• Purity: 95%

DETAILS

Toronto Research Chemicals - P699200

Practolol is a selective adrenergic β-receptor blocking drug with antihyperstensive activity. Practolol has been used in the emergency treatment of cardiac arrhythmias.

REFERENCES

• Estler, C.J. et al.: J. Pharm. Pharmacol., 21, 554 (1969)
• Taylor, S.H. et al.: Int. J. Clin. Pharmacol. Biopharm., 12, 305 (1969)
• Hoskins, E.J. et al.: Res. Comm. Chem. Pathol. Pharmacol., 21, 165 (1969)