2-[(4R)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide

• ChemBase ID: 175970
• Molecular Formular: C6H10N2O3
• Molecular Mass: 158.1552
• Monoisotopic Mass: 158.06914219
• SMILES: C1(=O)C[C@H](CN1CC(=O)N)O
• Canonical SMILES: NC(=O)CN1C[C@@H](CC1=O)O
• InChI: InChI=1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)/t4-/m1/s1
• InChIKey: IHLAQQPQKRMGSS-SCSAIBSYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 2-[(4R)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide
• IUPAC Traditional name: 2-[(4R)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide
• Synonyms: (4R)-4-Hydroxy-2-oxo-1-pyrrolidineacetamide; R-(+)-Oxiracetam

Database IDs

• CAS Number: 68252-28-8
• PubChem SID: 164231880
• PubChem CID: 3051965

CALCULATED PROPERTIES

• Acid pKa: 14.608332
• H Acceptors: 3
• H Donor: 2
• LogD (pH = 5.5): -2.6038888
• LogD (pH = 7.4): -2.6038888
• Log P: -2.6038888
• Molar Refractivity: 36.2689 cm^3
• Polarizability: 14.242021 Å^3
• Polar Surface Area: 83.63 Å^2
• Rotatable Bonds: 2
• Lipinski's Rule of Five: true

DETAILS

Toronto Research Chemicals - O846920

An oxiracetam (O846905) enantiomer with less potency as a nootropic than its (-)-S enantiomer.

REFERENCES

• Son, J., et al.: J. Pharm. Biomed. Anal., 36, 657 (2004)
• Hlinak, Z., et al.: Behaviour. Brain Res., 161, 213 (2004)