phosphoperoxol ethyl (4R,5S)-5-amino-4-(2H3)acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

• ChemBase ID: 175942
• Molecular Formular: C16H29N2O8P
• Molecular Mass: 408.383821
• Monoisotopic Mass: 408.16615253
• SMILES: [C@H]1([C@@H](CC(=CC1OC(CC)CC)C(=O)OCC)N)NC(=O)C.P(=O)(=O)OO
• Canonical SMILES: OOP(=O)=O.CCOC(=O)C1=CC([C@@H]([C@@H](C1)N)NC(=O)C)OC(CC)CC
• InChI: InChI=1S/C16H28N2O4.HO4P/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19;1-4-5(2)3/h9,12-15H,5-8,17H2,1-4H3,(H,18,19);1H/t13-,14?,15+;/m0./s1
• InChIKey: JBTFXCKJYNSRNQ-SBCPFMEFSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: phosphoperoxol ethyl (4R,5S)-5-amino-4-(^2H₃)acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
• IUPAC Traditional name: phosphoperoxol ethyl (4R,5S)-5-amino-4-(^2H₃)acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
• Synonyms: (3R,4R,5S)-4-(Acetylamino-d3)-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic Acid Ethyl Ester Phosphate; Oseltamir-d3 Phosphate; Ro 64-0796/002-d3; Tamiflu-d3; Oseltamivir-d3 Phosphate

Database IDs

• PubChem SID: 164231852
• PubChem CID: 71751350

CALCULATED PROPERTIES

• Acid pKa: 14.033634
• H Acceptors: 4
• H Donor: 2
• LogD (pH = 5.5): -1.8032612
• LogD (pH = 7.4): -0.7199175
• Log P: 1.1625985
• Molar Refractivity: 84.2034 cm^3
• Polarizability: 33.440342 Å^3
• Polar Surface Area: 90.65 Å^2
• Rotatable Bonds: 9
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: Methanol; Water
• Apperance: White Solid
• Melting Point: 190-192°C

Safety Information

• Storage Condition: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Storage Warning: Hygroscopic

DETAILS

Toronto Research Chemicals - O701002

Labelled Oseltamivir (O701000). Orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug.

REFERENCES

• Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998)
• Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998)
• Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1998)
• Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)