(2R)-2-amino-4-{4-[(1E)-{[(3S)-1-[(S)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl}(hydroxyimino)methyl]phenoxy}(4,4-2H2)butanoic acid

• ChemBase ID: 175463
• Molecular Formular: C23H24N4O9
• Molecular Mass: 501.4514689
• Monoisotopic Mass: 501.15136326
• SMILES: c1(ccc(cc1)/C(=[15N]\O)/C(=O)N[C@H]1CN(C1=O)[C@@H](c1ccc(cc1)O)C(=O)O)OCC[C@@H](N)C(=O)O
• Canonical SMILES: O/[15N]=C(\c1ccc(cc1)OCC[C@H](C(=O)O)N)/C(=O)N[C@H]1CN(C1=O)[C@@H](c1ccc(cc1)O)C(=O)O
• InChI: InChI=1S/C23H24N4O9/c24-16(22(31)32)9-10-36-15-7-3-12(4-8-15)18(26-35)20(29)25-17-11-27(21(17)30)19(23(33)34)13-1-5-14(28)6-2-13/h1-8,16-17,19,28,35H,9-11,24H2,(H,25,29)(H,31,32)(H,33,34)/b26-18+/t16-,17+,19+/m1/s1/i26+1
• InChIKey: CTNZOGJNVIFEBA-PDLWDZTMSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (2R)-2-amino-4-{4-[(1E)-{[(3S)-1-[(S)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl}(hydroxyimino)methyl]phenoxy}(4,4-^2H₂)butanoic acid
• IUPAC Traditional name: (2R)-2-amino-4-{4-[(1E)-{[(3S)-1-[(S)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl}(hydroxyimino)methyl]phenoxy}(4,4-^2H₂)butanoic acid
• Synonyms: (αR,3S)-3-[[(2Z)-2-[4-[(3R)-3-Amino-3-carboxypropoxy]phenyl]-2-(hydroxyimino)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic Acid-15N,d2; Nocardicin A-15N,d2; (αR,3S)-3-[[(2E)-[4-[(3R)-3-Amino-3-carboxypropoxy]phenyl](hydroxyimino)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic Acid-15N,d2; Nocardicin B-15N,d2

Database IDs

• PubChem SID: 164231373
• PubChem CID: 71751132

CALCULATED PROPERTIES

• Acid pKa: 1.7427144
• H Acceptors: 11
• H Donor: 6
• LogD (pH = 5.5): -4.735509
• LogD (pH = 7.4): -6.9160576
• Log P: -2.4572067
• Molar Refractivity: 121.8045 cm^3
• Polarizability: 47.32079 Å^3
• Polar Surface Area: 212.08 Å^2
• Rotatable Bonds: 11
• Lipinski's Rule of Five: false

DETAILS

Toronto Research Chemicals - N634012

Labelled Nocardicin B (N634010). Nocardicin B is a β-lactam antibiotic.

Toronto Research Chemicals - N634002

Labelled Nocardicin A (N634000). Nocardicin A is a labelled β-lactam antibiotic.

REFERENCES

• Yoshimura, F., et al.: Antimicrob. Agents Chemother., 27, 84 (1985)
• Mendez, R., et al.: Chem. Pharm. Bull., 40, 3222 (1992)
• Reeve, A., et al.: J. Biol. Chem., 273, 30695 (1992)